Latest Posts
PennPRS: A Web Tool for Polygenic Risk Scores with Summarized Genetic Data
Genome sequencing results can be used to train PRS models but suffer from computation and privacy limitations. A new web portal from Drs. Jin Jin and Bingxin Zhao uses GWAS summary statistics and novel pseudo-training methods to make the latest generation of PRS models more accessible.
Our Progress and Future – Pei-Chuan Ho, PhD Interview
ur first batch of genetic data is available, and the quality is outstanding, indicating the sample collection protocol is robust. Since most ACAD participants are immigrants, immigration experience (languages, education, occupation transitions) could be a unique feature in disease development. Analyzing lifestyle data highlights the importance of the environment in AD risks and how genetics may interact with major life transitions.
Looking to Explore AD Genomics? Check out NIAGADS Alzheimer’s Genomics Database
The Alzheimer’s Genomics Database is a user-friendly AD-centric interactive knowledgebase and genome browser, which provides unrestricted access to GWAS summary statistics from the NIAGADS repository, as well as to annotated variants called from ongoing the Alzheimer’s Disease Sequencing Project’s (ADSP) joint-genotype calling efforts. We sat down with Dr. Emily Greenfest-Allen, the architect of the Alzheimer’s Genomics Database, […]
Turning a Negative into a Neutral: Kaylyn Clark
Sixth year PHD Student, Kaylyn Clark discusses how she found herself in genetics and where she sees her future.
Using Functional Genomics to Decode Neurodegeneration – Towfique Raj PhD
Last month, PNGC had the pleasure of hosting Dr. Towfique Raj, PhD in partnership with the Perelman School of Medicine for the Biomedical Data Science Seminar Series. Dr. Raj is an Associate Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. His seminar addressed the post-GWAS challenges of variant and gene prioritization. […]