Selected Publications

2021:

  1. Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease.
    Zhang, X, Farrell, JJ, Tong, T, Hu, J, Zhu, C, Alzheimer's Disease Sequencing Project, Wang, LS, Mayeux, R, Haines, JL, Pericak-Vance, MA et al..
    Alzheimers Dement. 2021; :. doi: 10.1002/alz.12396.
    PubMed PMID:34152079 .
  2. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
    de Rojas, I, Moreno-Grau, S, Tesi, N, Grenier-Boley, B, Andrade, V, Jansen, IE, Pedersen, NL, Stringa, N, Zettergren, A, Hernández, I et al..
    Nat Commun. 2021;12 (1):3417. doi: 10.1038/s41467-021-22491-8.
    PubMed PMID:34099642 PubMed Central PMC8184987.
  3. Gene-Environment Interactions in Progressive Supranuclear Palsy.
    Litvan, I, Proudfoot, JA, Martin, ER, Standaert, D, Riley, D, Hall, D, Marras, C, Bayram, E, Dubinsky, RM, Bordelon, Y et al..
    Front Neurol. 2021;12 :664796. doi: 10.3389/fneur.2021.664796.
    PubMed PMID:33897612 PubMed Central PMC8062875.
  4. Reconcile the debate over protective effects of BCG vaccine against COVID-19.
    Fu, W, Ho, PC, Liu, CL, Tzeng, KT, Nayeem, N, Moore, JS, Wang, LS, Chou, SY.
    Sci Rep. 2021;11 (1):8356. doi: 10.1038/s41598-021-87731-9.
    PubMed PMID:33863950 PubMed Central PMC8052320.
  5. Latent trait modeling of tau neuropathology in progressive supranuclear palsy.
    Kouri, N, Murray, ME, Reddy, JS, Serie, DJ, Soto-Beasley, A, Allen, M, Carrasquillo, MM, Wang, X, Castanedes, MC, Baker, MC et al..
    Acta Neuropathol. 2021;141 (5):667-680. doi: 10.1007/s00401-021-02289-0.
    PubMed PMID:33635380 PubMed Central PMC8043857.
  6. Tailor: Targeting heavy tails in flow cytometry data with fast, interpretable mixture modeling.
    Ionita, M, Schretzenmair, R, Jones, D, Moore, J, Wang, LS, Rogers, W.
    Cytometry A. 2021;99 (2):133-144. doi: 10.1002/cyto.a.24307.
    PubMed PMID:33476090 .
  7. In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics.
    Xu, H, O'Reilly, M, Gibbons, GS, Changolkar, L, McBride, JD, Riddle, DM, Zhang, B, Stieber, A, Nirschl, J, Kim, SJ et al..
    Acta Neuropathol. 2021;141 (2):193-215. doi: 10.1007/s00401-020-02253-4.
    PubMed PMID:33385254 PubMed Central PMC7847465.
  8. Using INFERNO to Infer the Molecular Mechanisms Underlying Noncoding Genetic Associations.
    Amlie-Wolf, A, Kuksa, PP, Lee, CY, Mlynarski, E, Leung, YY, Wang, LS.
    Methods Mol Biol. 2021;2254 :73-91. doi: 10.1007/978-1-0716-1158-6_6.
    PubMed PMID:33326071 .
  9. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.
    Kunkle, BW, Schmidt, M, Klein, HU, Naj, AC, Hamilton-Nelson, KL, Larson, EB, Evans, DA, De Jager, PL, Crane, PK, Buxbaum, JD et al..
    JAMA Neurol. 2021;78 (1):102-113. doi: 10.1001/jamaneurol.2020.3536.
    PubMed PMID:33074286 PubMed Central PMC7573798.

2020:

  1. Author Correction: An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease.
    Nativio, R, Lan, Y, Donahue, G, Sidoli, S, Berson, A, Srinivasan, AR, Shcherbakova, O, Amlie-Wolf, A, Nie, J, Cui, X et al..
    Nat Genet. 2020;52 (11):1266. doi: 10.1038/s41588-020-00733-7.
    PubMed PMID:33033384 PubMed Central PMC8145746.
  2. An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease.
    Nativio, R, Lan, Y, Donahue, G, Sidoli, S, Berson, A, Srinivasan, AR, Shcherbakova, O, Amlie-Wolf, A, Nie, J, Cui, X et al..
    Nat Genet. 2020;52 (10):1024-1035. doi: 10.1038/s41588-020-0696-0.
    PubMed PMID:32989324 PubMed Central PMC8098004.
  3. Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R.
    Sandberg, A, Ling, H, Gearing, M, Dombroski, B, Cantwell, L, R'Bibo, L, Levey, A, Schellenberg, GD, Hardy, J, Wood, N et al..
    Neurobiol Dis. 2020;146 :105079. doi: 10.1016/j.nbd.2020.105079.
    PubMed PMID:32961270 .
  4. Genetic variants and functional pathways associated with resilience to Alzheimer's disease.
    Dumitrescu, L, Mahoney, ER, Mukherjee, S, Lee, ML, Bush, WS, Engelman, CD, Lu, Q, Fardo, DW, Trittschuh, EH, Mez, J et al..
    Brain. 2020;143 (8):2561-2575. doi: 10.1093/brain/awaa209.
    PubMed PMID:32844198 PubMed Central PMC7447518.
  5. Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo.
    Weitzman, SA, Narasimhan, S, He, Z, Changolkar, L, McBride, JD, Zhang, B, Schellenberg, GD, Trojanowski, JQ, Lee, VMY.
    J Neuropathol Exp Neurol. 2020;79 (9):941-949. doi: 10.1093/jnen/nlaa086.
    PubMed PMID:32838419 PubMed Central PMC7445034.
  6. A Coordinated Approach by Public Domain Bioinformatics Resources to Aid the Fight Against Alzheimer's Disease Through Expert Curation of Key Protein Targets.
    Breuza, L, Arighi, CN, Argoud-Puy, G, Casals-Casas, C, Estreicher, A, Famiglietti, ML, Georghiou, G, Gos, A, Gruaz-Gumowski, N, Hinz, U et al..
    J Alzheimers Dis. 2020;77 (1):257-273. doi: 10.3233/JAD-200206.
    PubMed PMID:32716361 PubMed Central PMC7592670.
  7. Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau.
    Kling, MA, Goodenowe, DB, Senanayake, V, MahmoudianDehkordi, S, Arnold, M, Massaro, TJ, Baillie, R, Han, X, Leung, YY, Saykin, AJ et al..
    Alzheimers Dement. 2020;16 (9):1234-1247. doi: 10.1002/alz.12110.
    PubMed PMID:32715599 PubMed Central PMC8152932.
  8. HiPR: High-throughput probabilistic RNA structure inference.
    Kuksa, PP, Li, F, Kannan, S, Gregory, BD, Leung, YY, Wang, LS.
    Comput Struct Biotechnol J. 2020;18 :1539-1547. doi: 10.1016/j.csbj.2020.06.004.
    PubMed PMID:32637050 PubMed Central PMC7327253.
  9. Sex-dependent autosomal effects on clinical progression of Alzheimer's disease.
    Fan, CC, Banks, SJ, Thompson, WK, Chen, CH, McEvoy, LK, Tan, CH, Kukull, W, Bennett, DA, Farrer, LA, Mayeux, R et al..
    Brain. 2020;143 (7):2272-2280. doi: 10.1093/brain/awaa164.
    PubMed PMID:32591829 PubMed Central PMC7364740.
  10. LRP10 variants in progressive supranuclear palsy.
    Vergouw, LJM, Melhem, S, Donker Kaat, L, Chiu, WZ, Kuipers, DJS, Breedveld, G, Boon, AJW, Wang, LS, Naj, AC, Mlynarksi, E et al..
    Neurobiol Aging. 2020;94 :311.e5-311.e10. doi: 10.1016/j.neurobiolaging.2020.04.016.
    PubMed PMID:32527607 PubMed Central PMC8281359.
  11. SparkINFERNO: a scalable high-throughput pipeline for inferring molecular mechanisms of non-coding genetic variants.
    Kuksa, PP, Lee, CY, Amlie-Wolf, A, Gangadharan, P, Mlynarski, EE, Chou, YF, Lin, HJ, Issen, H, Greenfest-Allen, E, Valladares, O et al..
    Bioinformatics. 2020;36 (12):3879-3881. doi: 10.1093/bioinformatics/btaa246.
    PubMed PMID:32330239 PubMed Central PMC7320617.
  12. HIPPIE2: a method for fine-scale identification of physically interacting chromatin regions.
    Kuksa, PP, Amlie-Wolf, A, Hwang, YC, Valladares, O, Gregory, BD, Wang, LS.
    NAR Genom Bioinform. 2020;2 (2):lqaa022. doi: 10.1093/nargab/lqaa022.
    PubMed PMID:32270138 PubMed Central PMC7106622.
  13. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
    Reiman, EM, Arboleda-Velasquez, JF, Quiroz, YT, Huentelman, MJ, Beach, TG, Caselli, RJ, Chen, Y, Su, Y, Myers, AJ, Hardy, J et al..
    Nat Commun. 2020;11 (1):667. doi: 10.1038/s41467-019-14279-8.
    PubMed PMID:32015339 PubMed Central PMC6997393.
  14. Transmission of tauopathy strains is independent of their isoform composition.
    He, Z, McBride, JD, Xu, H, Changolkar, L, Kim, SJ, Zhang, B, Narasimhan, S, Gibbons, GS, Guo, JL, Kozak, M et al..
    Nat Commun. 2020;11 (1):7. doi: 10.1038/s41467-019-13787-x.
    PubMed PMID:31911587 PubMed Central PMC6946697.
  15. Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
    Bis, JC, Jian, X, Kunkle, BW, Chen, Y, Hamilton-Nelson, KL, Bush, WS, Salerno, WJ, Lancour, D, Ma, Y, Renton, AE et al..
    Mol Psychiatry. 2020;25 (8):1901-1903. doi: 10.1038/s41380-019-0529-7.
    PubMed PMID:31636380 PubMed Central PMC7387240.
  16. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
    Bis, JC, Jian, X, Kunkle, BW, Chen, Y, Hamilton-Nelson, KL, Bush, WS, Salerno, WJ, Lancour, D, Ma, Y, Renton, AE et al..
    Mol Psychiatry. 2020;25 (8):1859-1875. doi: 10.1038/s41380-018-0112-7.
    PubMed PMID:30108311 PubMed Central PMC6375806.

2019:

  1. Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.
    Wheeler, JM, McMillan, P, Strovas, TJ, Liachko, NF, Amlie-Wolf, A, Kow, RL, Klein, RL, Szot, P, Robinson, L, Guthrie, C et al..
    Sci Transl Med. 2019;11 (523):. doi: 10.1126/scitranslmed.aao6545.
    PubMed PMID:31852801 PubMed Central PMC7311111.
  2. Inferring the Molecular Mechanisms of Noncoding Alzheimer's Disease-Associated Genetic Variants.
    Amlie-Wolf, A, Tang, M, Way, J, Dombroski, B, Jiang, M, Vrettos, N, Chou, YF, Zhao, Y, Kuzma, A, Mlynarski, EE et al..
    J Alzheimers Dis. 2019;72 (1):301-318. doi: 10.3233/JAD-190568.
    PubMed PMID:31561366 PubMed Central PMC7316086.
  3. Sex differences in the genetic predictors of Alzheimer's pathology.
    Dumitrescu, L, Barnes, LL, Thambisetty, M, Beecham, G, Kunkle, B, Bush, WS, Gifford, KA, Chibnik, LB, Mukherjee, S, De Jager, PL et al..
    Brain. 2019;142 (9):2581-2589. doi: 10.1093/brain/awz206.
    PubMed PMID:31497858 PubMed Central PMC6736148.
  4. APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE ε4 on Alzheimer's Disease Risk in a Multiracial Sample.
    Choi, KY, Lee, JJ, Gunasekaran, TI, Kang, S, Lee, W, Jeong, J, Lim, HJ, Zhang, X, Zhu, C, Won, SY et al..
    J Clin Med. 2019;8 (8):. doi: 10.3390/jcm8081236.
    PubMed PMID:31426376 PubMed Central PMC6723529.
  5. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
    Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A et al..
    Nat Genet. 2019;51 (9):1423-1424. doi: 10.1038/s41588-019-0495-7.
    PubMed PMID:31417202 PubMed Central PMC7265117.
  6. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy.
    Cali, CP, Patino, M, Tai, YK, Ho, WY, McLean, CA, Morris, CM, Seeley, WW, Miller, BL, Gaig, C, Vonsattel, JPG et al..
    Acta Neuropathol. 2019;138 (5):795-811. doi: 10.1007/s00401-019-02045-5.
    PubMed PMID:31327044 PubMed Central PMC6802287.
  7. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease.
    Baker, E, Sims, R, Leonenko, G, Frizzati, A, Harwood, JC, Grozeva, D, GERAD/PERADES, CHARGE, ADGC, EADI et al..
    PLoS One. 2019;14 (7):e0218111. doi: 10.1371/journal.pone.0218111.
    PubMed PMID:31283791 PubMed Central PMC6613773.
  8. Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.
    Ma, Y, Jun, GR, Zhang, X, Chung, J, Naj, AC, Chen, Y, Bellenguez, C, Hamilton-Nelson, K, Martin, ER, Kunkle, BW et al..
    JAMA Neurol. 2019;76 (9):1099-1108. doi: 10.1001/jamaneurol.2019.1456.
    PubMed PMID:31180460 PubMed Central PMC6563544.
  9. CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.
    Ma, Y, Jun, GR, Chung, J, Zhang, X, Kunkle, BW, Naj, AC, White, CC, Bennett, DA, De Jager, PL, Alzheimer’s Disease Genetics Consortium et al..
    Aging Cell. 2019;18 (4):e12964. doi: 10.1111/acel.12964.
    PubMed PMID:31144443 PubMed Central PMC6612647.
  10. VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project.
    Leung, YY, Valladares, O, Chou, YF, Lin, HJ, Kuzma, AB, Cantwell, L, Qu, L, Gangadharan, P, Salerno, WJ, Schellenberg, GD et al..
    Bioinformatics. 2019;35 (11):1985. doi: 10.1093/bioinformatics/btz216.
    PubMed PMID:31004159 PubMed Central PMC6546126.
  11. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
    Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A et al..
    Nat Genet. 2019;51 (3):414-430. doi: 10.1038/s41588-019-0358-2.
    PubMed PMID:30820047 PubMed Central PMC6463297.
  12. Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration.
    Tan, CH, Bonham, LW, Fan, CC, Mormino, EC, Sugrue, LP, Broce, IJ, Hess, CP, Yokoyama, JS, Rabinovici, GD, Miller, BL et al..
    Brain. 2019;142 (2):460-470. doi: 10.1093/brain/awy327.
    PubMed PMID:30689776 PubMed Central PMC6351776.
  13. DASHR 2.0: integrated database of human small non-coding RNA genes and mature products.
    Kuksa, PP, Amlie-Wolf, A, Katanić, Ž, Valladares, O, Wang, LS, Leung, YY.
    Bioinformatics. 2019;35 (6):1033-1039. doi: 10.1093/bioinformatics/bty709.
    PubMed PMID:30668832 PubMed Central PMC6419920.
  14. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.
    Chauhan, G, Adams, HHH, Satizabal, CL, Bis, JC, Teumer, A, Sargurupremraj, M, Hofer, E, Trompet, S, Hilal, S, Smith, AV et al..
    Neurology. 2019; :. doi: 10.1212/WNL.0000000000006851.
    PubMed PMID:30651383 PubMed Central PMC6369905.
  15. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease.
    Zhang, X, Zhu, C, Beecham, G, Vardarajan, BN, Ma, Y, Lancour, D, Farrell, JJ, Chung, J, Alzheimer's Disease Sequencing Project, Mayeux, R et al..
    Alzheimers Dement. 2019;15 (3):441-452. doi: 10.1016/j.jalz.2018.10.005.
    PubMed PMID:30503768 PubMed Central PMC6408965.
  16. Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.
    Urtishak, KA, Wang, LS, Culjkovic-Kraljacic, B, Davenport, JW, Porazzi, P, Vincent, TL, Teachey, DT, Tasian, SK, Moore, JS, Seif, AE et al..
    Oncogene. 2019;38 (13):2241-2262. doi: 10.1038/s41388-018-0567-7.
    PubMed PMID:30478448 PubMed Central PMC6440839.
  17. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease.
    Broce, IJ, Tan, CH, Fan, CC, Jansen, I, Savage, JE, Witoelar, A, Wen, N, Hess, CP, Dillon, WP, Glastonbury, CM et al..
    Acta Neuropathol. 2019;137 (2):209-226. doi: 10.1007/s00401-018-1928-6.
    PubMed PMID:30413934 PubMed Central PMC6358498.
  18. VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project.
    Leung, YY, Valladares, O, Chou, YF, Lin, HJ, Kuzma, AB, Cantwell, L, Qu, L, Gangadharan, P, Salerno, WJ, Schellenberg, GD et al..
    Bioinformatics. 2019;35 (10):1768-1770. doi: 10.1093/bioinformatics/bty894.
    PubMed PMID:30351394 PubMed Central PMC6513159.
  19. Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project.
    Naj, AC, Lin, H, Vardarajan, BN, White, S, Lancour, D, Ma, Y, Schmidt, M, Sun, F, Butkiewicz, M, Bush, WS et al..
    Genomics. 2019;111 (4):808-818. doi: 10.1016/j.ygeno.2018.05.004.
    PubMed PMID:29857119 PubMed Central PMC6397097.

2018:

  1. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations.
    Rajabli, F, Feliciano, BE, Celis, K, Hamilton-Nelson, KL, Whitehead, PL, Adams, LD, Bussies, PL, Manrique, CP, Rodriguez, A, Rodriguez, V et al..
    PLoS Genet. 2018;14 (12):e1007791. doi: 10.1371/journal.pgen.1007791.
    PubMed PMID:30517106 PubMed Central PMC6281216.
  2. Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.
    Urtishak, KA, Wang, LS, Culjkovic-Kraljacic, B, Davenport, JW, Porazzi, P, Vincent, TL, Teachey, DT, Tasian, SK, Moore, JS, Seif, AE et al..
    Oncogene. 2019;38 (13):2241-2262. doi: 10.1038/s41388-018-0567-7.
    PubMed PMID:30478448 PubMed Central PMC6440839.
  3. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease.
    Broce, IJ, Tan, CH, Fan, CC, Jansen, I, Savage, JE, Witoelar, A, Wen, N, Hess, CP, Dillon, WP, Glastonbury, CM et al..
    Acta Neuropathol. 2019;137 (2):209-226. doi: 10.1007/s00401-018-1928-6.
    PubMed PMID:30413934 PubMed Central PMC6358498.
  4. Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease.
    Gusareva, ES, Twizere, JC, Sleegers, K, Dourlen, P, Abisambra, JF, Meier, S, Cloyd, R, Weiss, B, Dermaut, B, Bessonov, K et al..
    Neurobiol Aging. 2018;72 :188.e3-188.e12. doi: 10.1016/j.neurobiolaging.2018.08.001.
    PubMed PMID:30201328 PubMed Central PMC6769421.
  5. INFERNO: inferring the molecular mechanisms of noncoding genetic variants.
    Amlie-Wolf, A, Tang, M, Mlynarski, EE, Kuksa, PP, Valladares, O, Katanic, Z, Tsuang, D, Brown, CD, Schellenberg, GD, Wang, LS et al..
    Nucleic Acids Res. 2018;46 (17):8740-8753. doi: 10.1093/nar/gky686.
    PubMed PMID:30113658 PubMed Central PMC6158604.
  6. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
    Bis, JC, Jian, X, Kunkle, BW, Chen, Y, Hamilton-Nelson, KL, Bush, WS, Salerno, WJ, Lancour, D, Ma, Y, Renton, AE et al..
    Mol Psychiatry. 2020;25 (8):1859-1875. doi: 10.1038/s41380-018-0112-7.
    PubMed PMID:30108311 PubMed Central PMC6375806.
  7. Integrative DNA copy number detection and genotyping from sequencing and array-based platforms.
    Zhou, Z, Wang, W, Wang, LS, Zhang, NR.
    Bioinformatics. 2018;34 (14):2349-2355. doi: 10.1093/bioinformatics/bty104.
    PubMed PMID:29992253 PubMed Central PMC6041760.
  8. Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci.
    Sanchez-Contreras, MY, Kouri, N, Cook, CN, Serie, DJ, Heckman, MG, Finch, NA, Caselli, RJ, Uitti, RJ, Wszolek, ZK, Graff-Radford, N et al..
    Mol Neurodegener. 2018;13 (1):37. doi: 10.1186/s13024-018-0267-3.
    PubMed PMID:29986742 PubMed Central PMC6038352.
  9. Sex-specific genetic predictors of Alzheimer's disease biomarkers.
    Deming, Y, Dumitrescu, L, Barnes, LL, Thambisetty, M, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S, De Jager, PL et al..
    Acta Neuropathol. 2018;136 (6):857-872. doi: 10.1007/s00401-018-1881-4.
    PubMed PMID:29967939 PubMed Central PMC6280657.
  10. Neuropsychiatric Symptoms and Caregiver Burden in Individuals With Alzheimer's Disease: The TEAM-AD VA Cooperative Study.
    Chen, P, Guarino, PD, Dysken, MW, Pallaki, M, Asthana, S, Llorente, MD, Love, S, Vertrees, JE, Schellenberg, GD, Sano, M et al..
    J Geriatr Psychiatry Neurol. 2018;31 (4):177-185. doi: 10.1177/0891988718783897.
    PubMed PMID:29966477 .
  11. Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project.
    Naj, AC, Lin, H, Vardarajan, BN, White, S, Lancour, D, Ma, Y, Schmidt, M, Sun, F, Butkiewicz, M, Bush, WS et al..
    Genomics. 2019;111 (4):808-818. doi: 10.1016/j.ygeno.2018.05.004.
    PubMed PMID:29857119 PubMed Central PMC6397097.
  12. Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.
    Hohman, TJ, Dumitrescu, L, Barnes, LL, Thambisetty, M, Beecham, G, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S et al..
    JAMA Neurol. 2018;75 (8):989-998. doi: 10.1001/jamaneurol.2018.0821.
    PubMed PMID:29801024 PubMed Central PMC6142927.
  13. SPAR: small RNA-seq portal for analysis of sequencing experiments.
    Kuksa, PP, Amlie-Wolf, A, Katanic, Ž, Valladares, O, Wang, LS, Leung, YY.
    Nucleic Acids Res. 2018;46 (W1):W36-W42. doi: 10.1093/nar/gky330.
    PubMed PMID:29733404 PubMed Central PMC6030839.
  14. Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease.
    Vardarajan, BN, Barral, S, Jaworski, J, Beecham, GW, Blue, E, Tosto, G, Reyes-Dumeyer, D, Medrano, M, Lantigua, R, Naj, A et al..
    Ann Clin Transl Neurol. 2018;5 (4):406-417. doi: 10.1002/acn3.537.
    PubMed PMID:29688227 PubMed Central PMC5899906.
  15. One for all and all for One: Improving replication of genetic studies through network diffusion.
    Lancour, D, Naj, A, Mayeux, R, Haines, JL, Pericak-Vance, MA, Schellenberg, GD, Crovella, M, Farrer, LA, Kasif, S.
    PLoS Genet. 2018;14 (4):e1007306. doi: 10.1371/journal.pgen.1007306.
    PubMed PMID:29684019 PubMed Central PMC5933817.
  16. CXCR4 involvement in neurodegenerative diseases.
    Bonham, LW, Karch, CM, Fan, CC, Tan, C, Geier, EG, Wang, Y, Wen, N, Broce, IJ, Li, Y, Barkovich, MJ et al..
    Transl Psychiatry. 2018;8 (1):73. doi: 10.1038/s41398-017-0049-7.
    PubMed PMID:29636460 PubMed Central PMC5893558.
  17. Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum.
    Karch, CM, Wen, N, Fan, CC, Yokoyama, JS, Kouri, N, Ross, OA, Höglinger, G, Müller, U, Ferrari, R, Hardy, J et al..
    JAMA Neurol. 2018;75 (7):860-875. doi: 10.1001/jamaneurol.2018.0372.
    PubMed PMID:29630712 PubMed Central PMC6043387.
  18. Functional annotation of genomic variants in studies of late-onset Alzheimer's disease.
    Butkiewicz, M, Blue, EE, Leung, YY, Jian, X, Marcora, E, Renton, AE, Kuzma, A, Wang, LS, Koboldt, DC, Haines, JL et al..
    Bioinformatics. 2018;34 (16):2724-2731. doi: 10.1093/bioinformatics/bty177.
    PubMed PMID:29590295 PubMed Central PMC6084586.
  19. Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.
    Nativio, R, Donahue, G, Berson, A, Lan, Y, Amlie-Wolf, A, Tuzer, F, Toledo, JB, Gosai, SJ, Gregory, BD, Torres, C et al..
    Nat Neurosci. 2018;21 (7):1018. doi: 10.1038/s41593-018-0124-2.
    PubMed PMID:29556027 .
  20. Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.
    Nativio, R, Donahue, G, Berson, A, Lan, Y, Amlie-Wolf, A, Tuzer, F, Toledo, JB, Gosai, SJ, Gregory, BD, Torres, C et al..
    Nat Neurosci. 2018;21 (4):497-505. doi: 10.1038/s41593-018-0101-9.
    PubMed PMID:29507413 PubMed Central PMC6124498.
  21. Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project.
    Blue, EE, Bis, JC, Dorschner, MO, Tsuang, DW, Barral, SM, Beecham, G, Below, JE, Bush, WS, Butkiewicz, M, Cruchaga, C et al..
    Dement Geriatr Cogn Disord. 2018;45 (1-2):1-17. doi: 10.1159/000485503.
    PubMed PMID:29486463 PubMed Central PMC5971141.
  22. Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.
    Teslovich, TM, Kim, DS, Yin, X, Stancáková, A, Jackson, AU, Wielscher, M, Naj, A, Perry, JRB, Huyghe, JR, Stringham, HM et al..
    Hum Mol Genet. 2018;27 (9):1664-1674. doi: 10.1093/hmg/ddy067.
    PubMed PMID:29481666 PubMed Central PMC5905595.
  23. Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
    Broce, I, Karch, CM, Wen, N, Fan, CC, Wang, Y, Tan, CH, Kouri, N, Ross, OA, Höglinger, GU, Muller, U et al..
    PLoS Med. 2018;15 (1):e1002504. doi: 10.1371/journal.pmed.1002504.
    PubMed PMID:29377952 PubMed Central PMC5788346.
  24. Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
    Broce, I, Karch, CM, Wen, N, Fan, CC, Wang, Y, Tan, CH, Kouri, N, Ross, OA, Höglinger, GU, Muller, U et al..
    PLoS Med. 2018;15 (1):e1002487. doi: 10.1371/journal.pmed.1002487.
    PubMed PMID:29315334 PubMed Central PMC5760014.
  25. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition.
    Tan, CH, Fan, CC, Mormino, EC, Sugrue, LP, Broce, IJ, Hess, CP, Dillon, WP, Bonham, LW, Yokoyama, JS, Karch, CM et al..
    Acta Neuropathol. 2018;135 (1):85-93. doi: 10.1007/s00401-017-1789-4.
    PubMed PMID:29177679 PubMed Central PMC5758038.

2017:

  1. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition.
    Tan, CH, Fan, CC, Mormino, EC, Sugrue, LP, Broce, IJ, Hess, CP, Dillon, WP, Bonham, LW, Yokoyama, JS, Karch, CM et al..
    Acta Neuropathol. 2018;135 (1):85-93. doi: 10.1007/s00401-017-1789-4.
    PubMed PMID:29177679 PubMed Central PMC5758038.
  2. Genetic influences on cognition in progressive supranuclear palsy.
    Gerstenecker, A, Roberson, ED, Schellenberg, GD, Standaert, DG, Shprecher, DR, Kluger, BM, Litvan, I.
    Mov Disord. 2017;32 (12):1764-1771. doi: 10.1002/mds.27196.
    PubMed PMID:29076559 PubMed Central PMC5818145.
  3. McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes.
    Hafez, D, Karabacak, A, Krueger, S, Hwang, YC, Wang, LS, Zinzen, RP, Ohler, U.
    Genome Biol. 2017;18 (1):199. doi: 10.1186/s13059-017-1316-x.
    PubMed PMID:29070071 PubMed Central PMC5657048.
  4. Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants.
    Rehker, J, Rodhe, J, Nesbitt, RR, Boyle, EA, Martin, BK, Lord, J, Karaca, I, Naj, A, Jessen, F, Helisalmi, S et al..
    PLoS One. 2017;12 (10):e0185777. doi: 10.1371/journal.pone.0185777.
    PubMed PMID:28985224 PubMed Central PMC5630132.
  5. Polygenic hazard scores in preclinical Alzheimer disease.
    Tan, CH, Hyman, BT, Tan, JJX, Hess, CP, Dillon, WP, Schellenberg, GD, Besser, LM, Kukull, WA, Kauppi, K, McEvoy, LK et al..
    Ann Neurol. 2017;82 (3):484-488. doi: 10.1002/ana.25029.
    PubMed PMID:28940650 PubMed Central PMC5758043.
  6. Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis.
    Neu, SC, Pa, J, Kukull, W, Beekly, D, Kuzma, A, Gangadharan, P, Wang, LS, Romero, K, Arneric, SP, Redolfi, A et al..
    JAMA Neurol. 2017;74 (10):1178-1189. doi: 10.1001/jamaneurol.2017.2188.
    PubMed PMID:28846757 PubMed Central PMC5759346.
  7. Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport.
    Kunkle, BW, Vardarajan, BN, Naj, AC, Whitehead, PL, Rolati, S, Slifer, S, Carney, RM, Cuccaro, ML, Vance, JM, Gilbert, JR et al..
    JAMA Neurol. 2017;74 (9):1113-1122. doi: 10.1001/jamaneurol.2017.1518.
    PubMed PMID:28738127 PubMed Central PMC5691589.
  8. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
    Sims, R, van der Lee, SJ, Naj, AC, Bellenguez, C, Badarinarayan, N, Jakobsdottir, J, Kunkle, BW, Boland, A, Raybould, R, Bis, JC et al..
    Nat Genet. 2017;49 (9):1373-1384. doi: 10.1038/ng.3916.
    PubMed PMID:28714976 PubMed Central PMC5669039.
  9. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
    Huang, KL, Marcora, E, Pimenova, AA, Di Narzo, AF, Kapoor, M, Jin, SC, Harari, O, Bertelsen, S, Fairfax, BP, Czajkowski, J et al..
    Nat Neurosci. 2017;20 (8):1052-1061. doi: 10.1038/nn.4587.
    PubMed PMID:28628103 PubMed Central PMC5759334.
  10. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.
    Höglinger, GU, Respondek, G, Stamelou, M, Kurz, C, Josephs, KA, Lang, AE, Mollenhauer, B, Müller, U, Nilsson, C, Whitwell, JL et al..
    Mov Disord. 2017;32 (6):853-864. doi: 10.1002/mds.26987.
    PubMed PMID:28467028 PubMed Central PMC5516529.
  11. In Silico Identification of RNA Modifications from High-Throughput Sequencing Data Using HAMR.
    Kuksa, PP, Leung, YY, Vandivier, LE, Anderson, Z, Gregory, BD, Wang, LS.
    Methods Mol Biol. 2017;1562 :211-229. doi: 10.1007/978-1-4939-6807-7_14.
    PubMed PMID:28349463 PubMed Central PMC7233376.
  12. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
    Desikan, RS, Fan, CC, Wang, Y, Schork, AJ, Cabral, HJ, Cupples, LA, Thompson, WK, Besser, L, Kukull, WA, Holland, D et al..
    PLoS Med. 2017;14 (3):e1002258. doi: 10.1371/journal.pmed.1002258.
    PubMed PMID:28323831 PubMed Central PMC5360219.
  13. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia.
    Yokoyama, JS, Karch, CM, Fan, CC, Bonham, LW, Kouri, N, Ross, OA, Rademakers, R, Kim, J, Wang, Y, Höglinger, GU et al..
    Acta Neuropathol. 2017;133 (5):825-837. doi: 10.1007/s00401-017-1693-y.
    PubMed PMID:28271184 PubMed Central PMC5429027.
  14. Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
    Jun, GR, Chung, J, Mez, J, Barber, R, Beecham, GW, Bennett, DA, Buxbaum, JD, Byrd, GS, Carrasquillo, MM, Crane, PK et al..
    Alzheimers Dement. 2017;13 (7):727-738. doi: 10.1016/j.jalz.2016.12.012.
    PubMed PMID:28183528 PubMed Central PMC5496797.
  15. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains.
    Haddick, PC, Larson, JL, Rathore, N, Bhangale, TR, Phung, QT, Srinivasan, K, Hansen, DV, Lill, JR, Alzheimer’s Disease Genetic Consortium (ADGC), Alzheimer’s Disease Neuroimaging Initiative (ADNI), Pericak-Vance, MA et al..
    J Alzheimers Dis. 2017;56 (3):1037-1054. doi: 10.3233/JAD-160524.
    PubMed PMID:28106546 PubMed Central PMC5667357.
  16. Genomic variants, genes, and pathways of Alzheimer's disease: An overview.
    Naj, AC, Schellenberg, GD, Alzheimer's Disease Genetics Consortium (ADGC).
    Am J Med Genet B Neuropsychiatr Genet. 2017;174 (1):5-26. doi: 10.1002/ajmg.b.32499.
    PubMed PMID:27943641 PubMed Central PMC6179157.
  17. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
    Chapuis, J, Flaig, A, Grenier-Boley, B, Eysert, F, Pottiez, V, Deloison, G, Vandeputte, A, Ayral, AM, Mendes, T, Desai, S et al..
    Acta Neuropathol. 2017;133 (6):955-966. doi: 10.1007/s00401-016-1652-z.
    PubMed PMID:27933404 PubMed Central PMC5427165.
  18. Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.
    Ferrari, R, Wang, Y, Vandrovcova, J, Guelfi, S, Witeolar, A, Karch, CM, Schork, AJ, Fan, CC, Brewer, JB, International FTD-Genomics Consortium (IFGC), et al..
    J Neurol Neurosurg Psychiatry. 2017;88 (2):152-164. doi: 10.1136/jnnp-2016-314411.
    PubMed PMID:27899424 PubMed Central PMC5237405.
  19. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.
    Mez, J, Chung, J, Jun, G, Kriegel, J, Bourlas, AP, Sherva, R, Logue, MW, Barnes, LL, Bennett, DA, Buxbaum, JD et al..
    Alzheimers Dement. 2017;13 (2):119-129. doi: 10.1016/j.jalz.2016.09.002.
    PubMed PMID:27770636 PubMed Central PMC5318231.

2016:

  1. Measuring informed consent capacity in an Alzheimer's disease clinical trial.
    Guarino, PD, Vertrees, JE, Asthana, S, Sano, M, Llorente, MD, Pallaki, M, Love, S, Schellenberg, GD, Dysken, MW.
    Alzheimers Dement (N Y). 2016;2 (4):258-266. doi: 10.1016/j.trci.2016.09.001.
    PubMed PMID:29067313 PubMed Central PMC5651363.
  2. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
    Chapuis, J, Flaig, A, Grenier-Boley, B, Eysert, F, Pottiez, V, Deloison, G, Vandeputte, A, Ayral, AM, Mendes, T, Desai, S et al..
    Acta Neuropathol. 2017;133 (6):955-966. doi: 10.1007/s00401-016-1652-z.
    PubMed PMID:27933404 PubMed Central PMC5427165.
  3. Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.
    Ferrari, R, Wang, Y, Vandrovcova, J, Guelfi, S, Witeolar, A, Karch, CM, Schork, AJ, Fan, CC, Brewer, JB, International FTD-Genomics Consortium (IFGC), et al..
    J Neurol Neurosurg Psychiatry. 2017;88 (2):152-164. doi: 10.1136/jnnp-2016-314411.
    PubMed PMID:27899424 PubMed Central PMC5237405.
  4. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.
    Mez, J, Chung, J, Jun, G, Kriegel, J, Bourlas, AP, Sherva, R, Logue, MW, Barnes, LL, Bennett, DA, Buxbaum, JD et al..
    Alzheimers Dement. 2017;13 (2):119-129. doi: 10.1016/j.jalz.2016.09.002.
    PubMed PMID:27770636 PubMed Central PMC5318231.
  5. Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease.
    Jakobsdottir, J, van der Lee, SJ, Bis, JC, Chouraki, V, Li-Kroeger, D, Yamamoto, S, Grove, ML, Naj, A, Vronskaya, M, Salazar, JL et al..
    PLoS Genet. 2016;12 (10):e1006327. doi: 10.1371/journal.pgen.1006327.
    PubMed PMID:27764101 PubMed Central PMC5072721.
  6. Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease.
    Bonham, LW, Geier, EG, Fan, CC, Leong, JK, Besser, L, Kukull, WA, Kornak, J, Andreassen, OA, Schellenberg, GD, Rosen, HJ et al..
    Ann Clin Transl Neurol. 2016;3 (9):668-77. doi: 10.1002/acn3.333.
    PubMed PMID:27648456 PubMed Central PMC5018579.
  7. Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence.
    Crowe, EP, Tuzer, F, Gregory, BD, Donahue, G, Gosai, SJ, Cohen, J, Leung, YY, Yetkin, E, Nativio, R, Wang, LS et al..
    Front Aging Neurosci. 2016;8 :208. doi: 10.3389/fnagi.2016.00208.
    PubMed PMID:27630559 PubMed Central PMC5005348.
  8. ABCA7 frameshift deletion associated with Alzheimer disease in African Americans.
    Cukier, HN, Kunkle, BW, Vardarajan, BN, Rolati, S, Hamilton-Nelson, KL, Kohli, MA, Whitehead, PL, Dombroski, BA, Van Booven, D, Lang, R et al..
    Neurol Genet. 2016;2 (3):e79. doi: 10.1212/NXG.0000000000000079.
    PubMed PMID:27231719 PubMed Central PMC4871806.
  9. A comprehensive database of high-throughput sequencing-based RNA secondary structure probing data (Structure Surfer).
    Berkowitz, ND, Silverman, IM, Childress, DM, Kazan, H, Wang, LS, Gregory, BD.
    BMC Bioinformatics. 2016;17 (1):215. doi: 10.1186/s12859-016-1071-0.
    PubMed PMID:27188311 PubMed Central PMC4869249.
  10. Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.
    Allen, M, Burgess, JD, Ballard, T, Serie, D, Wang, X, Younkin, CS, Sun, Z, Kouri, N, Baheti, S, Wang, C et al..
    Acta Neuropathol. 2016;132 (2):197-211. doi: 10.1007/s00401-016-1576-7.
    PubMed PMID:27115769 PubMed Central PMC4947429.
  11. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.
    Yokoyama, JS, Wang, Y, Schork, AJ, Thompson, WK, Karch, CM, Cruchaga, C, McEvoy, LK, Witoelar, A, Chen, CH, Holland, D et al..
    JAMA Neurol. 2016;73 (6):691-7. doi: 10.1001/jamaneurol.2016.0150.
    PubMed PMID:27088644 PubMed Central PMC4905783.
  12. Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease.
    Kohli, MA, Cukier, HN, Hamilton-Nelson, KL, Rolati, S, Kunkle, BW, Whitehead, PL, Züchner, SL, Farrer, LA, Martin, ER, Beecham, GW et al..
    Neurol Genet. 2016;2 (1):e41. doi: 10.1212/NXG.0000000000000041.
    PubMed PMID:27066578 PubMed Central PMC4817909.
  13. Assessment of the genetic variance of late-onset Alzheimer's disease.
    Ridge, PG, Hoyt, KB, Boehme, K, Mukherjee, S, Crane, PK, Haines, JL, Mayeux, R, Farrer, LA, Pericak-Vance, MA, Schellenberg, GD et al..
    Neurobiol Aging. 2016;41 :200.e13-200.e20. doi: 10.1016/j.neurobiolaging.2016.02.024.
    PubMed PMID:27036079 PubMed Central PMC4948179.
  14. Unique Familial MLL(KMT2A)-Rearranged Precursor B-Cell Infant Acute Lymphoblastic Leukemia in Non-twin Siblings.
    Urtishak, KA, Robinson, BW, Rappaport, EF, Sarezky, MD, Biegel, JA, Nichols, KE, Wilmoth, DM, Wang, LS, Stern, JW, Felix, CA et al..
    Pediatr Blood Cancer. 2016;63 (7):1175-80. doi: 10.1002/pbc.25957.
    PubMed PMID:26999444 .
  15. Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.
    Hohman, TJ, Bush, WS, Jiang, L, Brown-Gentry, KD, Torstenson, ES, Dudek, SM, Mukherjee, S, Naj, A, Kunkle, BW, Ritchie, MD et al..
    Neurobiol Aging. 2016;38 :141-150. doi: 10.1016/j.neurobiolaging.2015.10.031.
    PubMed PMID:26827652 PubMed Central PMC4735733.
  16. DASHR: database of small human noncoding RNAs.
    Leung, YY, Kuksa, PP, Amlie-Wolf, A, Valladares, O, Ungar, LH, Kannan, S, Gregory, BD, Wang, LS.
    Nucleic Acids Res. 2016;44 (D1):D216-22. doi: 10.1093/nar/gkv1188.
    PubMed PMID:26553799 PubMed Central PMC4702848.
  17. Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease.
    Kunkle, BW, Jaworski, J, Barral, S, Vardarajan, B, Beecham, GW, Martin, ER, Cantwell, LS, Partch, A, Bird, TD, Raskind, WH et al..
    Alzheimers Dement. 2016;12 (1):2-10. doi: 10.1016/j.jalz.2015.05.020.
    PubMed PMID:26365416 PubMed Central PMC4717829.
  18. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.
    Hohman, TJ, Cooke-Bailey, JN, Reitz, C, Jun, G, Naj, A, Beecham, GW, Liu, Z, Carney, RM, Vance, JM, Cuccaro, ML et al..
    Alzheimers Dement. 2016;12 (3):233-43. doi: 10.1016/j.jalz.2015.02.012.
    PubMed PMID:26092349 PubMed Central PMC4681680.

2015:

  1. Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.
    Hohman, TJ, Bush, WS, Jiang, L, Brown-Gentry, KD, Torstenson, ES, Dudek, SM, Mukherjee, S, Naj, A, Kunkle, BW, Ritchie, MD et al..
    Neurobiol Aging. 2016;38 :141-150. doi: 10.1016/j.neurobiolaging.2015.10.031.
    PubMed PMID:26827652 PubMed Central PMC4735733.
  2. Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study.
    Leung, YY, Toledo, JB, Nefedov, A, Polikar, R, Raghavan, N, Xie, SX, Farnum, M, Schultz, T, Baek, Y, Deerlin, VV et al..
    Alzheimers Dement (Amst). 2015;1 (3):339-348. doi: 10.1016/j.dadm.2015.06.008.
    PubMed PMID:26693175 PubMed Central PMC4672388.
  3. Chemical Modifications Mark Alternatively Spliced and Uncapped Messenger RNAs in Arabidopsis.
    Vandivier, LE, Campos, R, Kuksa, PP, Silverman, IM, Wang, LS, Gregory, BD.
    Plant Cell. 2015;27 (11):3024-37. doi: 10.1105/tpc.15.00591.
    PubMed PMID:26561561 PubMed Central PMC4682304.
  4. DASHR: database of small human noncoding RNAs.
    Leung, YY, Kuksa, PP, Amlie-Wolf, A, Valladares, O, Ungar, LH, Kannan, S, Gregory, BD, Wang, LS.
    Nucleic Acids Res. 2016;44 (D1):D216-22. doi: 10.1093/nar/gkv1188.
    PubMed PMID:26553799 PubMed Central PMC4702848.
  5. Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin.
    Amlie-Wolf, A, Ryvkin, P, Tong, R, Dragomir, I, Suh, E, Xu, Y, Van Deerlin, VM, Gregory, BD, Kwong, LK, Trojanowski, JQ et al..
    PLoS One. 2015;10 (10):e0141836. doi: 10.1371/journal.pone.0141836.
    PubMed PMID:26510133 PubMed Central PMC4624943.
  6. Common polygenic variation enhances risk prediction for Alzheimer's disease.
    Escott-Price, V, Sims, R, Bannister, C, Harold, D, Vronskaya, M, Majounie, E, Badarinarayan, N, GERAD/PERADES, IGAP consortia, Morgan, K et al..
    Brain. 2015;138 (Pt 12):3673-84. doi: 10.1093/brain/awv268.
    PubMed PMID:26490334 PubMed Central PMC5006219.
  7. Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease.
    Barral, S, Cheng, R, Reitz, C, Vardarajan, B, Lee, J, Kunkle, B, Beecham, G, Cantwell, LS, Pericak-Vance, MA, Farrer, LA et al..
    Alzheimers Dement. 2015;11 (12):1397-1406. doi: 10.1016/j.jalz.2015.07.487.
    PubMed PMID:26433351 PubMed Central PMC4690771.
  8. Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.
    Ghani, M, Reitz, C, Cheng, R, Vardarajan, BN, Jun, G, Sato, C, Naj, A, Rajbhandary, R, Wang, LS, Valladares, O et al..
    JAMA Neurol. 2015;72 (11):1313-23. doi: 10.1001/jamaneurol.2015.1700.
    PubMed PMID:26366463 PubMed Central PMC4641052.
  9. Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease.
    Kunkle, BW, Jaworski, J, Barral, S, Vardarajan, B, Beecham, GW, Martin, ER, Cantwell, LS, Partch, A, Bird, TD, Raskind, WH et al..
    Alzheimers Dement. 2016;12 (1):2-10. doi: 10.1016/j.jalz.2015.05.020.
    PubMed PMID:26365416 PubMed Central PMC4717829.
  10. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.
    Hohman, TJ, Cooke-Bailey, JN, Reitz, C, Jun, G, Naj, A, Beecham, GW, Liu, Z, Carney, RM, Vance, JM, Cuccaro, ML et al..
    Alzheimers Dement. 2016;12 (3):233-43. doi: 10.1016/j.jalz.2015.02.012.
    PubMed PMID:26092349 PubMed Central PMC4681680.
  11. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.
    Kouri, N, Ross, OA, Dombroski, B, Younkin, CS, Serie, DJ, Soto-Ortolaza, A, Baker, M, Finch, NCA, Yoon, H, Kim, J et al..
    Nat Commun. 2015;6 :7247. doi: 10.1038/ncomms8247.
    PubMed PMID:26077951 PubMed Central PMC4469997.
  12. Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis.
    Caulin, AF, Graham, TA, Wang, LS, Maley, CC.
    Philos Trans R Soc Lond B Biol Sci. 2015;370 (1673):. doi: 10.1098/rstb.2014.0222.
    PubMed PMID:26056366 PubMed Central PMC4581027.
  13. High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration.
    Wheeler, JM, McMillan, PJ, Hawk, M, Iba, M, Robinson, L, Xu, GJ, Dombroski, BA, Jeong, D, Dichter, MA, Juul, H et al..
    Acta Neuropathol Commun. 2015;3 :33. doi: 10.1186/s40478-015-0210-6.
    PubMed PMID:26041339 PubMed Central PMC4453289.
  14. The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.
    Lill, CM, Rengmark, A, Pihlstrøm, L, Fogh, I, Shatunov, A, Sleiman, PM, Wang, LS, Liu, T, Lassen, CF, Meissner, E et al..
    Alzheimers Dement. 2015;11 (12):1407-1416. doi: 10.1016/j.jalz.2014.12.009.
    PubMed PMID:25936935 PubMed Central PMC4627856.
  15. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.
    Desikan, RS, Schork, AJ, Wang, Y, Thompson, WK, Dehghan, A, Ridker, PM, Chasman, DI, McEvoy, LK, Holland, D, Chen, CH et al..
    Circulation. 2015;131 (23):2061-2069. doi: 10.1161/CIRCULATIONAHA.115.015489.
    PubMed PMID:25862742 PubMed Central PMC4677995.
  16. Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
    Wang, LS, Naj, AC, Graham, RR, Crane, PK, Kunkle, BW, Cruchaga, C, Murcia, JD, Cannon-Albright, L, Baldwin, CT, Zetterberg, H et al..
    JAMA Neurol. 2015;72 (2):209-16. doi: 10.1001/jamaneurol.2014.2157.
    PubMed PMID:25531812 PubMed Central PMC4324097.
  17. HIPPIE: a high-throughput identification pipeline for promoter interacting enhancer elements.
    Hwang, YC, Lin, CF, Valladares, O, Malamon, J, Kuksa, PP, Zheng, Q, Gregory, BD, Wang, LS.
    Bioinformatics. 2015;31 (8):1290-2. doi: 10.1093/bioinformatics/btu801.
    PubMed PMID:25480377 PubMed Central PMC4393516.
  18. Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology.
    Nelson, PT, Wang, WX, Partch, AB, Monsell, SE, Valladares, O, Ellingson, SR, Wilfred, BR, Naj, AC, Wang, LS, Kukull, WA et al..
    J Neuropathol Exp Neurol. 2015;74 (1):75-84. doi: 10.1097/NEN.0000000000000151.
    PubMed PMID:25470345 PubMed Central PMC4270894.

2014:

  1. HIPPIE: a high-throughput identification pipeline for promoter interacting enhancer elements.
    Hwang, YC, Lin, CF, Valladares, O, Malamon, J, Kuksa, PP, Zheng, Q, Gregory, BD, Wang, LS.
    Bioinformatics. 2015;31 (8):1290-2. doi: 10.1093/bioinformatics/btu801.
    PubMed PMID:25480377 PubMed Central PMC4393516.
  2. Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia.
    Warmus, BA, Sekar, DR, McCutchen, E, Schellenberg, GD, Roberts, RC, McMahon, LL, Roberson, ED.
    J Neurosci. 2014;34 (49):16482-95. doi: 10.1523/JNEUROSCI.3418-14.2014.
    PubMed PMID:25471585 PubMed Central PMC4252555.
  3. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
    Wetzel-Smith, MK, Hunkapiller, J, Bhangale, TR, Srinivasan, K, Maloney, JA, Atwal, JK, Sa, SM, Yaylaoglu, MB, Foreman, O, Ortmann, W et al..
    Nat Med. 2014;20 (12):1452-7. doi: 10.1038/nm.3736.
    PubMed PMID:25419706 PubMed Central PMC4301587.
  4. Synaptic, transcriptional and chromatin genes disrupted in autism.
    De Rubeis, S, He, X, Goldberg, AP, Poultney, CS, Samocha, K, Cicek, AE, Kou, Y, Liu, L, Fromer, M, Walker, S et al..
    Nature. 2014;515 (7526):209-15. doi: 10.1038/nature13772.
    PubMed PMID:25363760 .
  5. Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels.
    Allen, M, Kachadoorian, M, Quicksall, Z, Zou, F, Chai, HS, Younkin, C, Crook, JE, Pankratz, VS, Carrasquillo, MM, Krishnan, S et al..
    Alzheimers Res Ther. 2014;6 (4):39. doi: 10.1186/alzrt268.
    PubMed PMID:25324900 .
  6. IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals.
    Walsh, MC, Pearce, EL, Cejas, PJ, Lee, J, Wang, LS, Choi, Y.
    J Immunol. 2014;193 (8):3992-4001. doi: 10.4049/jimmunol.1400396.
    PubMed PMID:25200954 .
  7. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
    Naj, AC, Jun, G, Reitz, C, Kunkle, BW, Perry, W, Park, YS, Beecham, GW, Rajbhandary, RA, Hamilton-Nelson, KL, Wang, LS et al..
    JAMA Neurol. 2014;71 (11):1394-404. doi: 10.1001/jamaneurol.2014.1491.
    PubMed PMID:25199842 .
  8. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.
    Beecham, GW, Hamilton, K, Naj, AC, Martin, ER, Huentelman, M, Myers, AJ, Corneveaux, JJ, Hardy, J, Vonsattel, JP, Younkin, SG et al..
    PLoS Genet. 2014;10 (9):e1004606. doi: 10.1371/journal.pgen.1004606.
    PubMed PMID:25188341 .
  9. A framework for the interpretation of de novo mutation in human disease.
    Samocha, KE, Robinson, EB, Sanders, SJ, Stevens, C, Sabo, A, McGrath, LM, Kosmicki, JA, Rehnström, K, Mallick, S, Kirby, A et al..
    Nat Genet. 2014;46 (9):944-50. doi: 10.1038/ng.3050.
    PubMed PMID:25086666 .
  10. Antisense-mediated Exon Skipping Decreases Tau Protein Expression: A Potential Therapy For Tauopathies.
    Sud, R, Geller, ET, Schellenberg, GD.
    Mol Ther Nucleic Acids. 2014;3 :e180. doi: 10.1038/mtna.2014.30.
    PubMed PMID:25072694 .
  11. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.
    Jun, G, Asai, H, Zeldich, E, Drapeau, E, Chen, C, Chung, J, Park, JH, Kim, S, Haroutunian, V, Foroud, T et al..
    Ann Neurol. 2014;76 (3):379-92. doi: 10.1002/ana.24219.
    PubMed PMID:25043464 .
  12. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
    Escott-Price, V, Bellenguez, C, Wang, LS, Choi, SH, Harold, D, Jones, L, Holmans, P, Gerrish, A, Vedernikov, A, Richards, A et al..
    PLoS One. 2014;9 (6):e94661. doi: 10.1371/journal.pone.0094661.
    PubMed PMID:24922517 .
  13. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
    Nelson, PT, Estus, S, Abner, EL, Parikh, I, Malik, M, Neltner, JH, Ighodaro, E, Wang, WX, Wilfred, BR, Wang, LS et al..
    Acta Neuropathol. 2014;127 (6):825-43. doi: 10.1007/s00401-014-1282-2.
    PubMed PMID:24770881 .
  14. Convergence of genes and cellular pathways dysregulated in autism spectrum disorders.
    Pinto, D, Delaby, E, Merico, D, Barbosa, M, Merikangas, A, Klei, L, Thiruvahindrapuram, B, Xu, X, Ziman, R, Wang, Z et al..
    Am J Hum Genet. 2014;94 (5):677-94. doi: 10.1016/j.ajhg.2014.03.018.
    PubMed PMID:24768552 .
  15. A scoring strategy combining statistics and functional genomics supports a possible role for common polygenic variation in autism.
    Carayol, J, Schellenberg, GD, Dombroski, B, Amiet, C, Génin, B, Fontaine, K, Rousseau, F, Vazart, C, Cohen, D, Frazier, TW et al..
    Front Genet. 2014;5 :33. doi: 10.3389/fgene.2014.00033.
    PubMed PMID:24600472 .
  16. Missense variant in TREML2 protects against Alzheimer's disease.
    Benitez, BA, Jin, SC, Guerreiro, R, Graham, R, Lord, J, Harold, D, Sims, R, Lambert, JC, Gibbs, JR, Bras, J et al..
    Neurobiol Aging. 2014;35 (6):1510.e19-26. doi: 10.1016/j.neurobiolaging.2013.12.010.
    PubMed PMID:24439484 .
  17. Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial.
    Dysken, MW, Sano, M, Asthana, S, Vertrees, JE, Pallaki, M, Llorente, M, Love, S, Schellenberg, GD, McCarten, JR, Malphurs, J et al..
    JAMA. 2014;311 (1):33-44. doi: 10.1001/jama.2013.282834.
    PubMed PMID:24381967 .
  18. Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration.
    McMillan, CT, Toledo, JB, Avants, BB, Cook, PA, Wood, EM, Suh, E, Irwin, DJ, Powers, J, Olm, C, Elman, L et al..
    Neurobiol Aging. 2014;35 (6):1473-82. doi: 10.1016/j.neurobiolaging.2013.11.029.
    PubMed PMID:24373676 .
  19. Using machine learning and high-throughput RNA sequencing to classify the precursors of small non-coding RNAs.
    Ryvkin, P, Leung, YY, Ungar, LH, Gregory, BD, Wang, LS.
    Methods. 2014;67 (1):28-35. doi: 10.1016/j.ymeth.2013.10.002.
    PubMed PMID:24145223 .
  20. Incidence rates of dementia, Alzheimer disease, and vascular dementia in the Japanese American population in Seattle, WA: the Kame Project.
    Borenstein, AR, Wu, Y, Bowen, JD, McCormick, WC, Uomoto, J, McCurry, SM, Schellenberg, GD, Larson, EB.
    Alzheimer Dis Assoc Disord. ;28 (1):23-9. doi: 10.1097/WAD.0b013e3182a2e32f.
    PubMed PMID:24045327 .
  21. Vitamin E and memantine in Alzheimer's disease: clinical trial methods and baseline data.
    Dysken, MW, Guarino, PD, Vertrees, JE, Asthana, S, Sano, M, Llorente, M, Pallaki, M, Love, S, Schellenberg, GD, McCarten, JR et al..
    Alzheimers Dement. 2014;10 (1):36-44. doi: 10.1016/j.jalz.2013.01.014.
    PubMed PMID:23583234 .

2013:

  1. Analyzing copy number variation using SNP array data: protocols for calling CNV and association tests.
    Lin, CF, Naj, AC, Wang, LS.
    Curr Protoc Hum Genet. 2013;79 :Unit 1.27. doi: 10.1002/0471142905.hg0127s79.
    PubMed PMID:24510649 .
  2. Missense variant in TREML2 protects against Alzheimer's disease.
    Benitez, BA, Jin, SC, Guerreiro, R, Graham, R, Lord, J, Harold, D, Sims, R, Lambert, JC, Gibbs, JR, Bras, J et al..
    Neurobiol Aging. 2014;35 (6):1510.e19-26. doi: 10.1016/j.neurobiolaging.2013.12.010.
    PubMed PMID:24439484 .
  3. Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration.
    McMillan, CT, Toledo, JB, Avants, BB, Cook, PA, Wood, EM, Suh, E, Irwin, DJ, Powers, J, Olm, C, Elman, L et al..
    Neurobiol Aging. 2014;35 (6):1473-82. doi: 10.1016/j.neurobiolaging.2013.11.029.
    PubMed PMID:24373676 .
  4. The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease.
    Stutzbach, LD, Xie, SX, Naj, AC, Albin, R, Gilman, S, PSP Genetics Study Group, Lee, VM, Trojanowski, JQ, Devlin, B, Schellenberg, GD et al..
    Acta Neuropathol Commun. 2013;1 :31. doi: 10.1186/2051-5960-1-31.
    PubMed PMID:24252572 .
  5. The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ.
    Kalimo, H, Lalowski, M, Bogdanovic, N, Philipson, O, Bird, TD, Nochlin, D, Schellenberg, GD, Brundin, R, Olofsson, T, Soliymani, R et al..
    Acta Neuropathol Commun. 2013;1 :60. doi: 10.1186/2051-5960-1-60.
    PubMed PMID:24252272 .
  6. Using machine learning and high-throughput RNA sequencing to classify the precursors of small non-coding RNAs.
    Ryvkin, P, Leung, YY, Ungar, LH, Gregory, BD, Wang, LS.
    Methods. 2014;67 (1):28-35. doi: 10.1016/j.ymeth.2013.10.002.
    PubMed PMID:24145223 .
  7. Analysis of nonlinear gene expression progression reveals extensive pathway and age-specific transitions in aging human brains.
    Cao, K, Ryvkin, P, Hwang, YC, Johnson, FB, Wang, LS.
    PLoS One. 2013;8 (10):e74578. doi: 10.1371/journal.pone.0074578.
    PubMed PMID:24098339 .
  8. Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes.
    He, X, Sanders, SJ, Liu, L, De Rubeis, S, Lim, ET, Sutcliffe, JS, Schellenberg, GD, Gibbs, RA, Daly, MJ, Buxbaum, JD et al..
    PLoS Genet. 2013;9 (8):e1003671. doi: 10.1371/journal.pgen.1003671.
    PubMed PMID:23966865 .
  9. DRAW+SneakPeek: analysis workflow and quality metric management for DNA-seq experiments.
    Lin, CF, Valladares, O, Childress, DM, Klevak, E, Geller, ET, Hwang, YC, Tsai, EA, Schellenberg, GD, Wang, LS.
    Bioinformatics. 2013;29 (19):2498-500. doi: 10.1093/bioinformatics/btt422.
    PubMed PMID:23943636 .
  10. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
    Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, SH, Ripke, S, Neale, BM, Faraone, SV, Purcell, SM, Perlis, RH, Mowry, BJ, Thapar, A, Goddard, ME et al..
    Nat Genet. 2013;45 (9):984-94. doi: 10.1038/ng.2711.
    PubMed PMID:23933821 .
  11. Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases.
    Arnold, SE, Toledo, JB, Appleby, DH, Xie, SX, Wang, LS, Baek, Y, Wolk, DA, Lee, EB, Miller, BL, Lee, VM et al..
    J Comp Neurol. 2013;521 (18):4339-55. doi: 10.1002/cne.23430.
    PubMed PMID:23881776 .
  12. Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records.
    McDavid, A, Crane, PK, Newton, KM, Crosslin, DR, McCormick, W, Weston, N, Ehrlich, K, Hart, E, Harrison, R, Kukull, WA et al..
    PLoS One. 2013;8 (6):e63481. doi: 10.1371/journal.pone.0063481.
    PubMed PMID:23762230 .
  13. Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence.
    Platt, JM, Ryvkin, P, Wanat, JJ, Donahue, G, Ricketts, MD, Barrett, SP, Waters, HJ, Song, S, Chavez, A, Abdallah, KO et al..
    Genes Dev. 2013;27 (12):1406-20. doi: 10.1101/gad.218776.113.
    PubMed PMID:23756653 .
  14. Whole exome sequencing reveals minimal differences between cell line and whole blood derived DNA.
    Schafer, CM, Campbell, NG, Cai, G, Yu, F, Makarov, V, Yoon, S, Daly, MJ, Gibbs, RA, Schellenberg, GD, Devlin, B et al..
    Genomics. 2013;102 (4):270-7. doi: 10.1016/j.ygeno.2013.05.005.
    PubMed PMID:23743231 .
  15. CoRAL: predicting non-coding RNAs from small RNA-sequencing data.
    Leung, YY, Ryvkin, P, Ungar, LH, Gregory, BD, Wang, LS.
    Nucleic Acids Res. 2013;41 (14):e137. doi: 10.1093/nar/gkt426.
    PubMed PMID:23700308 .
  16. Analysis of rare, exonic variation amongst subjects with autism spectrum disorders and population controls.
    Liu, L, Sabo, A, Neale, BM, Nagaswamy, U, Stevens, C, Lim, E, Bodea, CA, Muzny, D, Reid, JG, Banks, E et al..
    PLoS Genet. 2013;9 (4):e1003443. doi: 10.1371/journal.pgen.1003443.
    PubMed PMID:23593035 .
  17. C9orf72 hexanucleotide repeat expansion and Guam amyotrophic lateral sclerosis-Parkinsonism-dementia complex.
    Dombroski, BA, Galasko, DR, Mata, IF, Zabetian, CP, Craig, UK, Garruto, RM, Oyanagi, K, Schellenberg, GD.
    JAMA Neurol. 2013;70 (6):742-5. doi: 10.1001/jamaneurol.2013.1817.
    PubMed PMID:23588498 .
  18. Vitamin E and memantine in Alzheimer's disease: clinical trial methods and baseline data.
    Dysken, MW, Guarino, PD, Vertrees, JE, Asthana, S, Sano, M, Llorente, M, Pallaki, M, Love, S, Schellenberg, GD, McCarten, JR et al..
    Alzheimers Dement. 2014;10 (1):36-44. doi: 10.1016/j.jalz.2013.01.014.
    PubMed PMID:23583234 .
  19. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
    Reitz, C, Jun, G, Naj, A, Rajbhandary, R, Vardarajan, BN, Wang, LS, Valladares, O, Lin, CF, Larson, EB, Graff-Radford, NR et al..
    JAMA. 2013;309 (14):1483-92. doi: 10.1001/jama.2013.2973.
    PubMed PMID:23571587 .
  20. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
    Miyashita, A, Koike, A, Jun, G, Wang, LS, Takahashi, S, Matsubara, E, Kawarabayashi, T, Shoji, M, Tomita, N, Arai, H et al..
    PLoS One. 2013;8 (4):e58618. doi: 10.1371/journal.pone.0058618.
    PubMed PMID:23565137 .
  21. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
    Cruchaga, C, Kauwe, JS, Harari, O, Jin, SC, Cai, Y, Karch, CM, Benitez, BA, Jeng, AT, Skorupa, T, Carrell, D et al..
    Neuron. 2013;78 (2):256-68. doi: 10.1016/j.neuron.2013.02.026.
    PubMed PMID:23562540 .
  22. High-throughput identification of long-range regulatory elements and their target promoters in the human genome.
    Hwang, YC, Zheng, Q, Gregory, BD, Wang, LS.
    Nucleic Acids Res. 2013;41 (9):4835-46. doi: 10.1093/nar/gkt188.
    PubMed PMID:23525463 .
  23. APOE ε4 increases risk for dementia in pure synucleinopathies.
    Tsuang, D, Leverenz, JB, Lopez, OL, Hamilton, RL, Bennett, DA, Schneider, JA, Buchman, AS, Larson, EB, Crane, PK, Kaye, JA et al..
    JAMA Neurol. 2013;70 (2):223-8. doi: 10.1001/jamaneurol.2013.600.
    PubMed PMID:23407718 .
  24. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.
    Holton, P, Ryten, M, Nalls, M, Trabzuni, D, Weale, ME, Hernandez, D, Crehan, H, Gibbs, JR, Mayeux, R, Haines, JL et al..
    Ann Hum Genet. 2013;77 (2):85-105. doi: 10.1111/ahg.12000.
    PubMed PMID:23360175 .
  25. Genome scan in familial late-onset Alzheimer's disease: a locus on chromosome 6 contributes to age-at-onset.
    Zhao, W, Marchani, EE, Cheung, CY, Steinbart, EJ, Schellenberg, GD, Bird, TD, Wijsman, EM.
    Am J Med Genet B Neuropsychiatr Genet. 2013;162B (2):201-12. doi: 10.1002/ajmg.b.32133.
    PubMed PMID:23355194 .
  26. Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders.
    Lim, ET, Raychaudhuri, S, Sanders, SJ, Stevens, C, Sabo, A, MacArthur, DG, Neale, BM, Kirby, A, Ruderfer, DM, Fromer, M et al..
    Neuron. 2013;77 (2):235-42. doi: 10.1016/j.neuron.2012.12.029.
    PubMed PMID:23352160 .
  27. Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementia.
    Arnold, SE, Vega, IE, Karlawish, JH, Wolk, DA, Nunez, J, Negron, M, Xie, SX, Wang, LS, Dubroff, JG, McCarty-Wood, E et al..
    J Alzheimers Dis. 2013;33 (4):1089-95. doi: 10.3233/JAD-2012-121570.
    PubMed PMID:23114514 .
  28. Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease.
    Arnold, SE, Louneva, N, Cao, K, Wang, LS, Han, LY, Wolk, DA, Negash, S, Leurgans, SE, Schneider, JA, Buchman, AS et al..
    Neurobiol Aging. 2013;34 (1):157-68. doi: 10.1016/j.neurobiolaging.2012.03.004.
    PubMed PMID:22554416 .

2012:

  1. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
    Whitcomb, DC, LaRusch, J, Krasinskas, AM, Klei, L, Smith, JP, Brand, RE, Neoptolemos, JP, Lerch, MM, Tector, M, Sandhu, BS et al..
    Nat Genet. 2012;44 (12):1349-54. doi: 10.1038/ng.2466.
    PubMed PMID:23143602 .
  2. GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.
    Tsuang, D, Leverenz, JB, Lopez, OL, Hamilton, RL, Bennett, DA, Schneider, JA, Buchman, AS, Larson, EB, Crane, PK, Kaye, JA et al..
    Neurology. 2012;79 (19):1944-50. doi: 10.1212/WNL.0b013e3182735e9a.
    PubMed PMID:23035075 .
  3. Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.
    Jun, G, Vardarajan, BN, Buros, J, Yu, CE, Hawk, MV, Dombroski, BA, Crane, PK, Larson, EB, Alzheimer's Disease Genetics Consortium, Mayeux, R et al..
    Arch Neurol. 2012;69 (10):1270-9. doi: 10.1001/archneurol.2012.2052.
    PubMed PMID:22869155 .
  4. Individual common variants exert weak effects on the risk for autism spectrum disorders.
    Anney, R, Klei, L, Pinto, D, Almeida, J, Bacchelli, E, Baird, G, Bolshakova, N, Bölte, S, Bolton, PF, Bourgeron, T et al..
    Hum Mol Genet. 2012;21 (21):4781-92. doi: 10.1093/hmg/dds301.
    PubMed PMID:22843504 .
  5. Global analysis of RNA secondary structure in two metazoans.
    Li, F, Zheng, Q, Ryvkin, P, Dragomir, I, Desai, Y, Aiyer, S, Valladares, O, Yang, J, Bambina, S, Sabin, LR et al..
    Cell Rep. 2012;1 (1):69-82. doi: 10.1016/j.celrep.2011.10.002.
    PubMed PMID:22832108 .
  6. Novel late-onset Alzheimer disease loci variants associate with brain gene expression.
    Allen, M, Zou, F, Chai, HS, Younkin, CS, Crook, J, Pankratz, VS, Carrasquillo, MM, Rowley, CN, Nair, AA, Middha, S et al..
    Neurology. 2012;79 (3):221-8. doi: 10.1212/WNL.0b013e3182605801.
    PubMed PMID:22722634 .
  7. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.
    Zou, F, Chai, HS, Younkin, CS, Allen, M, Crook, J, Pankratz, VS, Carrasquillo, MM, Rowley, CN, Nair, AA, Middha, S et al..
    PLoS Genet. 2012;8 (6):e1002707. doi: 10.1371/journal.pgen.1002707.
    PubMed PMID:22685416 .
  8. The genetics and neuropathology of Alzheimer's disease.
    Schellenberg, GD, Montine, TJ.
    Acta Neuropathol. 2012;124 (3):305-23. doi: 10.1007/s00401-012-0996-2.
    PubMed PMID:22618995 .
  9. Comparison of xMAP and ELISA assays for detecting cerebrospinal fluid biomarkers of Alzheimer's disease.
    Wang, LS, Leung, YY, Chang, SK, Leight, S, Knapik-Czajka, M, Baek, Y, Shaw, LM, Lee, VM, Trojanowski, JQ, Clark, CM et al..
    J Alzheimers Dis. 2012;31 (2):439-45. doi: 10.3233/JAD-2012-120082.
    PubMed PMID:22571982 .
  10. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.
    Coppola, G, Chinnathambi, S, Lee, JJ, Dombroski, BA, Baker, MC, Soto-Ortolaza, AI, Lee, SE, Klein, E, Huang, AY, Sears, R et al..
    Hum Mol Genet. 2012;21 (15):3500-12. doi: 10.1093/hmg/dds161.
    PubMed PMID:22556362 .
  11. Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease.
    Arnold, SE, Louneva, N, Cao, K, Wang, LS, Han, LY, Wolk, DA, Negash, S, Leurgans, SE, Schneider, JA, Buchman, AS et al..
    Neurobiol Aging. 2013;34 (1):157-68. doi: 10.1016/j.neurobiolaging.2012.03.004.
    PubMed PMID:22554416 .
  12. Patterns and rates of exonic de novo mutations in autism spectrum disorders.
    Neale, BM, Kou, Y, Liu, L, Ma'ayan, A, Samocha, KE, Sabo, A, Lin, CF, Stevens, C, Wang, LS, Makarov, V et al..
    Nature. 2012;485 (7397):242-5. doi: 10.1038/nature11011.
    PubMed PMID:22495311 .
  13. SAVoR: a server for sequencing annotation and visualization of RNA structures.
    Li, F, Ryvkin, P, Childress, DM, Valladares, O, Gregory, BD, Wang, LS.
    Nucleic Acids Res. 2012;40 (Web Server issue):W59-64. doi: 10.1093/nar/gks310.
    PubMed PMID:22492627 .
  14. Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms.
    Irwin, DJ, McMillan, CT, Toledo, JB, Arnold, SE, Shaw, LM, Wang, LS, Van Deerlin, V, Lee, VM, Trojanowski, JQ, Grossman, M et al..
    Arch Neurol. 2012;69 (8):1018-25. doi: 10.1001/archneurol.2012.26.
    PubMed PMID:22490326 .
  15. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study.
    Majounie, E, Renton, AE, Mok, K, Dopper, EG, Waite, A, Rollinson, S, Chiò, A, Restagno, G, Nicolaou, N, Simon-Sanchez, J et al..
    Lancet Neurol. 2012;11 (4):323-30. doi: 10.1016/S1474-4422(12)70043-1.
    PubMed PMID:22406228 .
  16. The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila.
    Liu, N, Landreh, M, Cao, K, Abe, M, Hendriks, GJ, Kennerdell, JR, Zhu, Y, Wang, LS, Bonini, NM.
    Nature. 2012;482 (7386):519-23. doi: 10.1038/nature10810.
    PubMed PMID:22343898 .
  17. A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.
    Casey, JP, Magalhaes, T, Conroy, JM, Regan, R, Shah, N, Anney, R, Shields, DC, Abrahams, BS, Almeida, J, Bacchelli, E et al..
    Hum Genet. 2012;131 (4):565-79. doi: 10.1007/s00439-011-1094-6.
    PubMed PMID:21996756 PubMed Central PMC3303079.

2011:

  1. An X chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males.
    Chung, RH, Ma, D, Wang, K, Hedges, DJ, Jaworski, JM, Gilbert, JR, Cuccaro, ML, Wright, HH, Abramson, RK, Konidari, I et al..
    Mol Autism. 2011;2 (1):18. doi: 10.1186/2040-2392-2-18.
    PubMed PMID:22050706 PubMed Central PMC3305893.
  2. Autism risk assessment in siblings of affected children using sex-specific genetic scores.
    Carayol, J, Schellenberg, GD, Dombroski, B, Genin, E, Rousseau, F, Dawson, G.
    Mol Autism. 2011;2 (1):17. doi: 10.1186/2040-2392-2-17.
    PubMed PMID:22017886 PubMed Central PMC3214848.
  3. A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.
    Casey, JP, Magalhaes, T, Conroy, JM, Regan, R, Shah, N, Anney, R, Shields, DC, Abrahams, BS, Almeida, J, Bacchelli, E et al..
    Hum Genet. 2012;131 (4):565-79. doi: 10.1007/s00439-011-1094-6.
    PubMed PMID:21996756 PubMed Central PMC3303079.
  4. Selection of individual VH genes occurs at the pro-B to pre-B cell transition.
    Meng, W, Yunk, L, Wang, LS, Maganty, A, Xue, E, Cohen, PL, Eisenberg, RA, Weigert, MG, Mancini, SJ, Prak, ET et al..
    J Immunol. 2011;187 (4):1835-44. doi: 10.4049/jimmunol.1100207.
    PubMed PMID:21746964 PubMed Central PMC3150439.
  5. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
    Höglinger, GU, Melhem, NM, Dickson, DW, Sleiman, PM, Wang, LS, Klei, L, Rademakers, R, de Silva, R, Litvan, I, Riley, DE et al..
    Nat Genet. 2011;43 (7):699-705. doi: 10.1038/ng.859.
    PubMed PMID:21685912 PubMed Central PMC3125476.
  6. The impact of multiple protein sequence alignment on phylogenetic estimation.
    Wang, LS, Leebens-Mack, J, Kerr Wall, P, Beckmann, K, dePamphilis, CW, Warnow, T.
    IEEE/ACM Trans Comput Biol Bioinform. ;8 (4):1108-19. doi: 10.1109/TCBB.2009.68.
    PubMed PMID:21566256 .
  7. Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.
    Chen-Plotkin, AS, Martinez-Lage, M, Sleiman, PM, Hu, W, Greene, R, Wood, EM, Bing, S, Grossman, M, Schellenberg, GD, Hatanpaa, KJ et al..
    Arch Neurol. 2011;68 (4):488-97. doi: 10.1001/archneurol.2011.53.
    PubMed PMID:21482928 PubMed Central PMC3160280.
  8. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
    Naj, AC, Jun, G, Beecham, GW, Wang, LS, Vardarajan, BN, Buros, J, Gallins, PJ, Buxbaum, JD, Jarvik, GP, Crane, PK et al..
    Nat Genet. 2011;43 (5):436-41. doi: 10.1038/ng.801.
    PubMed PMID:21460841 PubMed Central PMC3090745.
  9. Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
    Jayadev, S, Nochlin, D, Poorkaj, P, Steinbart, EJ, Mastrianni, JA, Montine, TJ, Ghetti, B, Schellenberg, GD, Bird, TD, Leverenz, JB et al..
    Ann Neurol. 2011;69 (4):712-20. doi: 10.1002/ana.22264.
    PubMed PMID:21416485 PubMed Central PMC3114566.
  10. Genome-scan for IQ discrepancy in autism: evidence for loci on chromosomes 10 and 16.
    Chapman, NH, Estes, A, Munson, J, Bernier, R, Webb, SJ, Rothstein, JH, Minshew, NJ, Dawson, G, Schellenberg, GD, Wijsman, EM et al..
    Hum Genet. 2011;129 (1):59-70. doi: 10.1007/s00439-010-0899-z.
    PubMed PMID:20963441 PubMed Central PMC3082447.

2010:

  1. Genome-scan for IQ discrepancy in autism: evidence for loci on chromosomes 10 and 16.
    Chapman, NH, Estes, A, Munson, J, Bernier, R, Webb, SJ, Rothstein, JH, Minshew, NJ, Dawson, G, Schellenberg, GD, Wijsman, EM et al..
    Hum Genet. 2011;129 (1):59-70. doi: 10.1007/s00439-010-0899-z.
    PubMed PMID:20963441 PubMed Central PMC3082447.
  2. Genome-wide double-stranded RNA sequencing reveals the functional significance of base-paired RNAs in Arabidopsis.
    Zheng, Q, Ryvkin, P, Li, F, Dragomir, I, Valladares, O, Yang, J, Cao, K, Wang, LS, Gregory, BD.
    PLoS Genet. 2010;6 (9):e1001141. doi: 10.1371/journal.pgen.1001141.
    PubMed PMID:20941385 PubMed Central PMC2947979.
  3. Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study.
    Han, MR, Schellenberg, GD, Wang, LS, Alzheimer's Disease Neuroimaging Initiative.
    BMC Neurol. 2010;10 :90. doi: 10.1186/1471-2377-10-90.
    PubMed PMID:20932310 PubMed Central PMC2964649.
  4. Age-correlated gene expression in normal and neurodegenerative human brain tissues.
    Cao, K, Chen-Plotkin, AS, Plotkin, JB, Wang, LS.
    PLoS One. 2010;5 (9):. doi: 10.1371/journal.pone.0013098.
    PubMed PMID:20927326 PubMed Central PMC2947518.
  5. Population-based study of genetic variation in individuals with autism spectrum disorders from Croatia.
    Wang, LS, Hranilovic, D, Wang, K, Lindquist, IE, Yurcaba, L, Petkovic, ZB, Gidaya, N, Jernej, B, Hakonarson, H, Bucan, M et al..
    BMC Med Genet. 2010;11 :134. doi: 10.1186/1471-2350-11-134.
    PubMed PMID:20858243 PubMed Central PMC2954843.
  6. Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability.
    Noor, A, Whibley, A, Marshall, CR, Gianakopoulos, PJ, Piton, A, Carson, AR, Orlic-Milacic, M, Lionel, AC, Sato, D, Pinto, D et al..
    Sci Transl Med. 2010;2 (49):49ra68. doi: 10.1126/scitranslmed.3001267.
    PubMed PMID:20844286 PubMed Central PMC2987731.
  7. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
    Jun, G, Naj, AC, Beecham, GW, Wang, LS, Buros, J, Gallins, PJ, Buxbaum, JD, Ertekin-Taner, N, Fallin, MD, Friedland, R et al..
    Arch Neurol. 2010;67 (12):1473-84. doi: 10.1001/archneurol.2010.201.
    PubMed PMID:20697030 PubMed Central PMC3048805.
  8. Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk.
    Carayol, J, Schellenberg, GD, Tores, F, Hager, J, Ziegler, A, Dawson, G.
    Mol Autism. 2010;1 (1):4. doi: 10.1186/2040-2392-1-4.
    PubMed PMID:20678243 PubMed Central PMC2907567.
  9. A genome-wide scan for common alleles affecting risk for autism.
    Anney, R, Klei, L, Pinto, D, Regan, R, Conroy, J, Magalhaes, TR, Correia, C, Abrahams, BS, Sykes, N, Pagnamenta, AT et al..
    Hum Mol Genet. 2010;19 (20):4072-82. doi: 10.1093/hmg/ddq307.
    PubMed PMID:20663923 PubMed Central PMC2947401.
  10. Age-varying association between statin use and incident Alzheimer's disease.
    Li, G, Shofer, JB, Rhew, IC, Kukull, WA, Peskind, ER, McCormick, W, Bowen, JD, Schellenberg, GD, Crane, PK, Breitner, JC et al..
    J Am Geriatr Soc. 2010;58 (7):1311-7. doi: 10.1111/j.1532-5415.2010.02906.x.
    PubMed PMID:20533968 PubMed Central PMC3176730.
  11. Functional impact of global rare copy number variation in autism spectrum disorders.
    Pinto, D, Pagnamenta, AT, Klei, L, Anney, R, Merico, D, Regan, R, Conroy, J, Magalhaes, TR, Correia, C, Abrahams, BS et al..
    Nature. 2010;466 (7304):368-72. doi: 10.1038/nature09146.
    PubMed PMID:20531469 PubMed Central PMC3021798.
  12. APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding.
    Koelle, DM, Magaret, A, Warren, T, Schellenberg, GD, Wald, A.
    Sex Transm Infect. 2010;86 (3):202-6. doi: 10.1136/sti.2009.039735.
    PubMed PMID:20410080 PubMed Central PMC2881187.
  13. Evidence for three loci modifying age-at-onset of Alzheimer's disease in early-onset PSEN2 families.
    Marchani, EE, Bird, TD, Steinbart, EJ, Rosenthal, E, Yu, CE, Schellenberg, GD, Wijsman, EM.
    Am J Med Genet B Neuropsychiatr Genet. 2010;153B (5):1031-41. doi: 10.1002/ajmg.b.31072.
    PubMed PMID:20333730 PubMed Central PMC3022037.
  14. Design of comprehensive Alzheimer's disease centers to address unmet national needs.
    Trojanowski, JQ, Arnold, SE, Karlawish, JH, Brunden, K, Cary, M, Davatzikos, C, Detre, J, Gaulton, G, Grossman, M, Hurtig, H et al..
    Alzheimers Dement. 2010;6 (2):150-5. doi: 10.1016/j.jalz.2009.11.004.
    PubMed PMID:20298979 PubMed Central PMC2842603.
  15. Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.
    Kraemer, BC, Schuck, T, Wheeler, JM, Robinson, LC, Trojanowski, JQ, Lee, VM, Schellenberg, GD.
    Acta Neuropathol. 2010;119 (4):409-19. doi: 10.1007/s00401-010-0659-0.
    PubMed PMID:20198480 PubMed Central PMC2880609.
  16. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
    Van Deerlin, VM, Sleiman, PM, Martinez-Lage, M, Chen-Plotkin, A, Wang, LS, Graff-Radford, NR, Dickson, DW, Rademakers, R, Boeve, BF, Grossman, M et al..
    Nat Genet. 2010;42 (3):234-9. doi: 10.1038/ng.536.
    PubMed PMID:20154673 PubMed Central PMC2828525.
  17. Effects of apolipoprotein E-epsilon4 and -epsilon2 in amnestic mild cognitive impairment and dementia in Shanghai: SCOBHI-P.
    Borenstein, AR, Mortimer, JA, Ding Ding,, Schellenberg, GD, DeCarli, C, Qianhua Zhao,, Copenhaver, C, Qihao Guo,, Shugang Chu,, Galasko, D et al..
    Am J Alzheimers Dis Other Demen. 2010;25 (3):233-8. doi: 10.1177/1533317509357736.
    PubMed PMID:20142627 PubMed Central PMC2872993.
  18. The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration.
    Yu, CE, Bird, TD, Bekris, LM, Montine, TJ, Leverenz, JB, Steinbart, E, Galloway, NM, Feldman, H, Woltjer, R, Miller, CA et al..
    Arch Neurol. 2010;67 (2):161-70. doi: 10.1001/archneurol.2009.328.
    PubMed PMID:20142524 PubMed Central PMC2901991.
  19. Correcting population stratification in genetic association studies using a phylogenetic approach.
    Li, M, Reilly, MP, Rader, DJ, Wang, LS.
    Bioinformatics. 2010;26 (6):798-806. doi: 10.1093/bioinformatics/btq025.
    PubMed PMID:20097913 PubMed Central PMC2832820.
  20. Computational approaches to the detection and analysis of sequences with intramolecular G-quadruplex forming potential.
    Ryvkin, P, Hershman, SG, Wang, LS, Johnson, FB.
    Methods Mol Biol. 2010;608 :39-50. doi: 10.1007/978-1-59745-363-9_3.
    PubMed PMID:20012414 PubMed Central PMC3713069.
  21. Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential.
    Johnson, JE, Cao, K, Ryvkin, P, Wang, LS, Johnson, FB.
    Nucleic Acids Res. 2010;38 (4):1114-22. doi: 10.1093/nar/gkp1103.
    PubMed PMID:19966276 PubMed Central PMC2831322.
  22. Visualizing disease associations: graphic analysis of frequency distributions as a function of age using moving average plots (MAP) with application to Alzheimer's and Parkinson's disease.
    Payami, H, Kay, DM, Zabetian, CP, Schellenberg, GD, Factor, SA, McCulloch, CC.
    Genet Epidemiol. 2010;34 (1):92-9. doi: 10.1002/gepi.20439.
    PubMed PMID:19582778 PubMed Central PMC2796703.
  23. APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure.
    Bekris, LM, Galloway, NM, Montine, TJ, Schellenberg, GD, Yu, CE.
    Am J Med Genet B Neuropsychiatr Genet. 2010;153B (2):409-417. doi: 10.1002/ajmg.b.30993.
    PubMed PMID:19554612 PubMed Central PMC2829359.

2009:

  1. Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential.
    Johnson, JE, Cao, K, Ryvkin, P, Wang, LS, Johnson, FB.
    Nucleic Acids Res. 2010;38 (4):1114-22. doi: 10.1093/nar/gkp1103.
    PubMed PMID:19966276 PubMed Central PMC2831322.
  2. Effects of insulin and octreotide on memory and growth hormone in Alzheimer's disease.
    Watson, GS, Baker, LD, Cholerton, BA, Rhoads, KW, Merriam, GR, Schellenberg, GD, Asthana, S, Cherrier, M, Craft, S.
    J Alzheimers Dis. 2009;18 (3):595-602. doi: 10.3233/JAD-2009-1165.
    PubMed PMID:19625744 PubMed Central PMC2842464.
  3. Identification of novel susceptibility loci for Guam neurodegenerative disease: challenges of genome scans in genetic isolates.
    Sieh, W, Choi, Y, Chapman, NH, Craig, UK, Steinbart, EJ, Rothstein, JH, Oyanagi, K, Garruto, RM, Bird, TD, Galasko, DR et al..
    Hum Mol Genet. 2009;18 (19):3725-38. doi: 10.1093/hmg/ddp300.
    PubMed PMID:19567404 PubMed Central PMC2742398.
  4. Creating a transatlantic research enterprise for preventing Alzheimer's disease.
    Khachaturian, ZS, Camí, J, Andrieu, S, Avila, J, Boada Rovira, M, Breteler, M, Froelich, L, Gauthier, S, Gómez-Isla, T, Khachaturian, AS et al..
    Alzheimers Dement. 2009;5 (4):361-6. doi: 10.1016/j.jalz.2009.05.158.
    PubMed PMID:19560106 PubMed Central PMC3295837.
  5. A Bayesian approach to efficient differential allocation for resampling-based significance testing.
    Jensen, ST, Soi, S, Wang, LS.
    BMC Bioinformatics. 2009;10 :198. doi: 10.1186/1471-2105-10-198.
    PubMed PMID:19558706 PubMed Central PMC2718927.
  6. Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.
    Bucan, M, Abrahams, BS, Wang, K, Glessner, JT, Herman, EI, Sonnenblick, LI, Alvarez Retuerto, AI, Imielinski, M, Hadley, D, Bradfield, JP et al..
    PLoS Genet. 2009;5 (6):e1000536. doi: 10.1371/journal.pgen.1000536.
    PubMed PMID:19557195 PubMed Central PMC2695001.
  7. Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
    Pearce, EL, Walsh, MC, Cejas, PJ, Harms, GM, Shen, H, Wang, LS, Jones, RG, Choi, Y.
    Nature. 2009;460 (7251):103-7. doi: 10.1038/nature08097.
    PubMed PMID:19494812 PubMed Central PMC2803086.
  8. Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings.
    Petrie, EC, Cross, DJ, Galasko, D, Schellenberg, GD, Raskind, MA, Peskind, ER, Minoshima, S.
    Arch Neurol. 2009;66 (5):632-7. doi: 10.1001/archneurol.2009.59.
    PubMed PMID:19433663 PubMed Central PMC2718788.
  9. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.
    Glessner, JT, Wang, K, Cai, G, Korvatska, O, Kim, CE, Wood, S, Zhang, H, Estes, A, Brune, CW, Bradfield, JP et al..
    Nature. 2009;459 (7246):569-73. doi: 10.1038/nature07953.
    PubMed PMID:19404257 PubMed Central PMC2925224.
  10. Common genetic variants on 5p14.1 associate with autism spectrum disorders.
    Wang, K, Zhang, H, Ma, D, Bucan, M, Glessner, JT, Abrahams, BS, Salyakina, D, Imielinski, M, Bradfield, JP, Sleiman, PM et al..
    Nature. 2009;459 (7246):528-33. doi: 10.1038/nature07999.
    PubMed PMID:19404256 PubMed Central PMC2943511.
  11. LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease.
    Zabetian, CP, Yamamoto, M, Lopez, AN, Ujike, H, Mata, IF, Izumi, Y, Kaji, R, Maruyama, H, Morino, H, Oda, M et al..
    Mov Disord. 2009;24 (7):1034-41. doi: 10.1002/mds.22514.
    PubMed PMID:19343804 PubMed Central PMC2827255.
  12. SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans.
    Guthrie, CR, Schellenberg, GD, Kraemer, BC.
    Hum Mol Genet. 2009;18 (10):1825-38. doi: 10.1093/hmg/ddp099.
    PubMed PMID:19273536 PubMed Central PMC2722225.
  13. Genomic landscape of a three-generation pedigree segregating affective disorder.
    Yang, S, Wang, K, Gregory, B, Berrettini, W, Wang, LS, Hakonarson, H, Bucan, M.
    PLoS One. 2009;4 (2):e4474. doi: 10.1371/journal.pone.0004474.
    PubMed PMID:19214233 PubMed Central PMC2637422.
  14. Mortality, dementia, and apolipoprotein E genotype in elderly white women in the United States.
    Little, DM, Crooks, VC, Petitti, DB, Chiu, V, Schellenberg, GD, Slezak, JM, Jacobsen, SJ.
    J Am Geriatr Soc. 2009;57 (2):231-6. doi: 10.1111/j.1532-5415.2008.02113.x.
    PubMed PMID:19207139 .
  15. The ALS/PDC syndrome of Guam and the cycad hypothesis.
    Borenstein, AR, Mortimer, JA, Schellenberg, GD, Galasko, D, McGeer, PL, Steele, JC.
    Neurology. 2009;72 (5):473, 476; author reply 475-6. doi: 10.1212/01.wnl.0000344257.59693.cf.
    PubMed PMID:19188582 .

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