2024:
- X-chromosome-wide association study for Alzheimer's disease.
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Mol Psychiatry. 2024; :. doi: 10.1038/s41380-024-02838-5.
PubMed PMID:39633006 . - Author Correction: Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes.
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Nat Commun. 2024;15 (1):9828. doi: 10.1038/s41467-024-53617-3.
PubMed PMID:39537593 PubMed Central PMC11561328. - Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites.
Tong, T, Zhu, C, Farrell, JJ, Khurshid, Z, Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Neuroimaging Initiative, Martin, ER, Pericak-Vance, MA, Wang, LS, Bush, WS, Schellenberg, GD et al..
Alzheimers Res Ther. 2024;16 (1):234. doi: 10.1186/s13195-024-01601-w.
PubMed PMID:39444005 PubMed Central PMC11515778. - Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project.
Lee, WP, Choi, SH, Shea, MG, Cheng, PL, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB et al..
Alzheimers Dement. 2024; :. doi: 10.1002/alz.14283.
PubMed PMID:39428839 . - Correction: Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy.
Wang, H, Chang, TS, Dombroski, BA, Cheng, PL, Patil, V, Valiente-Banuet, L, Farrell, K, Mclean, C, Molina-Porcel, L, Rajput, A et al..
Mol Neurodegener. 2024;19 (1):73. doi: 10.1186/s13024-024-00763-3.
PubMed PMID:39402686 PubMed Central PMC11475913. - GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia.
Shade, LMP, Katsumata, Y, Abner, EL, Aung, KZ, Claas, SA, Qiao, Q, Heberle, BA, Brandon, JA, Page, ML, Hohman, TJ et al..
Nat Genet. 2024;56 (11):2407-2421. doi: 10.1038/s41588-024-01939-9.
PubMed PMID:39379761 PubMed Central PMC11549054. - Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes.
Farrell, K, Humphrey, J, Chang, T, Zhao, Y, Leung, YY, Kuksa, PP, Patil, V, Lee, WP, Kuzma, AB, Valladares, O et al..
Nat Commun. 2024;15 (1):7880. doi: 10.1038/s41467-024-52025-x.
PubMed PMID:39251599 PubMed Central PMC11385559. - Variant-to-function mapping of late-onset Alzheimer's disease GWAS signals in human microglial cell models implicates RTFDC1 at the CASS4 locus.
Burton, EA, Argenziano, M, Cook, K, Ridler, M, Lu, S, Su, C, Manduchi, E, Littleton, SH, Leonard, ME, Hodge, KM et al..
bioRxiv. 2024; :. doi: 10.1101/2024.08.22.609230.
PubMed PMID:39229212 PubMed Central PMC11370593. - Asian Cohort for Alzheimer Disease (ACAD) Pilot Study: Vietnamese Americans.
Peavy, GM, Võ, N, Revta, C, Lu, AT, Lupo, JL, Nam, P, Nguyễn, KH, Wang, LS, Feldman, HH.
Alzheimer Dis Assoc Disord. ;38 (3):277-284. doi: 10.1097/WAD.0000000000000631.
PubMed PMID:39177172 PubMed Central PMC11340683. - Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy.
Wang, H, Chang, TS, Dombroski, BA, Cheng, PL, Patil, V, Valiente-Banuet, L, Farrell, K, Mclean, C, Molina-Porcel, L, Rajput, A et al..
Mol Neurodegener. 2024;19 (1):61. doi: 10.1186/s13024-024-00747-3.
PubMed PMID:39152475 PubMed Central PMC11330058. - Region-based analysis with functional annotation identifies genes associated with cognitive function in South Asians from India.
Abu-Amara, H, Zhao, W, Li, Z, Leung, YY, Schellenberg, GD, Wang, LS, Moorjani, P, Dey, AB, Dey, S, Zhou, X et al..
Res Sq. 2024; :. doi: 10.21203/rs.3.rs-4712660/v1.
PubMed PMID:39149469 PubMed Central PMC11326367. - A Specialized Reference Panel with Structural Variants Integration for Improving Genotype Imputation in Alzheimer's Disease and Related Dementias (ADRD).
Cheng, PL, Wang, H, Dombroski, BA, Farrell, JJ, Horng, I, Chung, T, Tosto, G, Kunkle, BW, Bush, WS, Vardarajan, B et al..
medRxiv. 2024; :. doi: 10.1101/2024.07.22.24310827.
PubMed PMID:39108532 PubMed Central PMC11302603. - Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.
Ray, NR, Kunkle, BW, Hamilton-Nelson, K, Kurup, JT, Rajabli, F, Qiao, M, Vardarajan, BN, Cosacak, MI, Kizil, C, Jean-Francois, M et al..
Alzheimers Dement. 2024;20 (8):5247-5261. doi: 10.1002/alz.13880.
PubMed PMID:38958117 PubMed Central PMC11350055. - Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV.
Akay-Espinoza, C, Newton, SEB, Dombroski, BA, Kallianpur, A, Bharti, A, Franklin, DR, Schellenberg, GD, Heaton, RK, Grant, I, Ellis, RJ et al..
J Neuroimmune Pharmacol. 2024;19 (1):25. doi: 10.1007/s11481-024-10125-x.
PubMed PMID:38789639 PubMed Central PMC11126443. - MitoH3: Mitochondrial Haplogroup and Homoplasmic/Heteroplasmic Variant Calling Pipeline for Alzheimer's Disease Sequencing Project.
Zhu, C, Tong, T, Farrell, JJ, Martin, ER, Bush, WS, Pericak-Vance, MA, Wang, LS, Schellenberg, GD, Haines, JL, Lunetta, KL et al..
J Alzheimers Dis Rep. 2024;8 (1):575-587. doi: 10.3233/ADR-230120.
PubMed PMID:38746629 PubMed Central PMC11091720. - A single dose for me, A wealth of protection for us: The public health cost of individualism in the rollout of COVID-19 vaccine.
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Soc Sci Med. 2024;348 :116849. doi: 10.1016/j.socscimed.2024.116849.
PubMed PMID:38581815 . - MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.
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PubMed PMID:38472475 PubMed Central PMC10933148. - Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and MAPT Sub-haplotypes.
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medRxiv. 2024; :. doi: 10.1101/2024.02.26.24303379.
PubMed PMID:38464214 PubMed Central PMC10925353. - A comparative study of structural variant calling in WGS from Alzheimer's disease families.
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Life Sci Alliance. 2024;7 (5):. doi: 10.26508/lsa.202302181.
PubMed PMID:38418088 PubMed Central PMC10902710. - 50,000 years of Evolutionary History of India: Insights from ~2,700 Whole Genome Sequences.
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bioRxiv. 2024; :. doi: 10.1101/2024.02.15.580575.
PubMed PMID:38405782 PubMed Central PMC10888882. - Region-based analysis with functional annotation identifies genes associated with cognitive function in South Asians from India.
Abu-Amara, H, Zhao, W, Li, Z, Leung, YY, Schellenberg, GD, Wang, LS, Moorjani, P, Dey, AB, Dey, S, Zhou, X et al..
medRxiv. 2024; :. doi: 10.1101/2024.01.18.24301482.
PubMed PMID:38293024 PubMed Central PMC10827235. - Human whole-exome genotype data for Alzheimer's disease.
Leung, YY, Naj, AC, Chou, YF, Valladares, O, Schmidt, M, Hamilton-Nelson, K, Wheeler, N, Lin, H, Gangadharan, P, Qu, L et al..
Nat Commun. 2024;15 (1):684. doi: 10.1038/s41467-024-44781-7.
PubMed PMID:38263370 PubMed Central PMC10805795. - Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy.
Wang, H, Chang, TS, Dombroski, BA, Cheng, PL, Patil, V, Valiente-Banuet, L, Farrell, K, Mclean, C, Molina-Porcel, L, Rajput, A et al..
medRxiv. 2024; :. doi: 10.1101/2023.12.28.23300612.
PubMed PMID:38234807 PubMed Central PMC10793533. - Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians.
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Alzheimers Dement. 2024;20 (3):2058-2071. doi: 10.1002/alz.13611.
PubMed PMID:38215053 PubMed Central PMC10984480. - Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.
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Ann Neurol. 2024;95 (4):625-634. doi: 10.1002/ana.26864.
PubMed PMID:38180638 . - Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.
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Alzheimers Dement. 2024;20 (2):1268-1283. doi: 10.1002/alz.13508.
PubMed PMID:37985223 PubMed Central PMC10896586. - Sex-specific genetic architecture of late-life memory performance.
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PubMed PMID:37984853 PubMed Central PMC10917043. - NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge.
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Alzheimers Dement. 2024;20 (2):1123-1136. doi: 10.1002/alz.13509.
PubMed PMID:37881831 PubMed Central PMC10916966. - DNA from multiple viral species is associated with Alzheimer's disease risk.
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Alzheimers Dement. 2024;20 (1):253-265. doi: 10.1002/alz.13414.
PubMed PMID:37578203 PubMed Central PMC10840621.
2023:
- Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease.
Guo, MH, Lee, WP, Vardarajan, B, Schellenberg, GD, Phillips-Cremins, J.
medRxiv. 2023; :. doi: 10.1101/2023.11.16.23298623.
PubMed PMID:38014121 PubMed Central PMC10680900. - Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.
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Alzheimers Dement. 2024;20 (2):1268-1283. doi: 10.1002/alz.13508.
PubMed PMID:37985223 PubMed Central PMC10896586. - Sex-specific genetic architecture of late-life memory performance.
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Alzheimers Dement. 2024;20 (2):1250-1267. doi: 10.1002/alz.13507.
PubMed PMID:37984853 PubMed Central PMC10917043. - hipFG: high-throughput harmonization and integration pipeline for functional genomics data.
Cifello, J, Kuksa, PP, Saravanan, N, Valladares, O, Wang, LS, Leung, YY.
Bioinformatics. 2023;39 (11):. doi: 10.1093/bioinformatics/btad673.
PubMed PMID:37947320 PubMed Central PMC10660288. - Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects.
Lee, WP, Wang, H, Dombroski, B, Cheng, PL, Tucci, A, Si, YQ, Farrell, J, Tzeng, JY, Leung, YY, Malamon, J et al..
Res Sq. 2023; :. doi: 10.21203/rs.3.rs-3353179/v1.
PubMed PMID:37886469 PubMed Central PMC10602095. - NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge.
Greenfest-Allen, E, Valladares, O, Kuksa, PP, Gangadharan, P, Lee, WP, Cifello, J, Katanic, Z, Kuzma, AB, Wheeler, N, Bush, WS et al..
Alzheimers Dement. 2024;20 (2):1123-1136. doi: 10.1002/alz.13509.
PubMed PMID:37881831 PubMed Central PMC10916966. - Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects.
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medRxiv. 2023; :. doi: 10.1101/2023.09.13.23295505.
PubMed PMID:37745545 PubMed Central PMC10516060. - Extended genome-wide association study employing the African Genome Resources Panel identifies novel susceptibility loci for Alzheimer's Disease in individuals of African ancestry.
Ray, NR, Kunkle, BW, Hamilton-Nelson, K, Kurup, JT, Rajabli, F, Cosacak, MI, Kizil, C, Jean-Francois, M, Cuccaro, M, Reyes-Dumeyer, D et al..
medRxiv. 2023; :. doi: 10.1101/2023.08.29.23294774.
PubMed PMID:37693582 PubMed Central PMC10491365. - Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project.
Lee, WP, Choi, SH, Shea, MG, Cheng, PL, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB et al..
medRxiv. 2023; :. doi: 10.1101/2023.09.01.23294953.
PubMed PMID:37693521 PubMed Central PMC10491367. - DNA from multiple viral species is associated with Alzheimer's disease risk.
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Alzheimers Dement. 2024;20 (1):253-265. doi: 10.1002/alz.13414.
PubMed PMID:37578203 PubMed Central PMC10840621. - The prediction of Alzheimer's disease through multi-trait genetic modeling.
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Front Aging Neurosci. 2023;15 :1168638. doi: 10.3389/fnagi.2023.1168638.
PubMed PMID:37577355 PubMed Central PMC10416111. - Using community-based geographical information system (GIS) to recruit older Asian Americans in an Alzheimer's disease study.
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BMJ Open. 2023;13 (8):e072761. doi: 10.1136/bmjopen-2023-072761.
PubMed PMID:37536975 PubMed Central PMC10401260. - Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.
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PubMed PMID:37461624 PubMed Central PMC10350126. - Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.
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JAMA Neurol. 2023;80 (9):929-939. doi: 10.1001/jamaneurol.2023.2169.
PubMed PMID:37459083 PubMed Central PMC10352930. - The Early-Onset Alzheimer's Disease Whole-Genome Sequencing Project: Study design and methodology.
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Alzheimers Dement. 2023;19 (9):4187-4195. doi: 10.1002/alz.13370.
PubMed PMID:37390458 PubMed Central PMC10527497. - A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.
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Mol Neurodegener. 2023;18 (1):40. doi: 10.1186/s13024-023-00633-4.
PubMed PMID:37349795 PubMed Central PMC10286470. - Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews.
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Alzheimers Dement. 2023;19 (12):5550-5562. doi: 10.1002/alz.13117.
PubMed PMID:37260021 PubMed Central PMC10689571. - hipFG: High-throughput harmonization and integration pipeline for functional genomics data.
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PubMed PMID:37162864 PubMed Central PMC10168270. - The role of structural variations in Alzheimer's disease and other neurodegenerative diseases.
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PubMed PMID:36759603 PubMed Central PMC9911386. - Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans.
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PubMed PMID:36539198 PubMed Central PMC10272044. - Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women.
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2022:
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PubMed PMID:36539198 PubMed Central PMC10272044. - Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease.
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