Penn Neurodegeneration
Genomics Center

Last November, former running back for the Cincinnati Bengals, Rudi Johnson, took his own life at the age of 45. His family linked his mental health with years of repeated injuries, and his agent hoped this would spur a larger conversation about the long-term impacts of Chronic Traumatic Encephalopathy (CTE). 

Penn Neurodegeneration Genomics Center (PNGC) is offering a Pilot AI Learning Series this semester.  Now underway, it brings together opportunities for discussion and practical training for researchers, trainees, and staff interested in applying AI tools to biomedical research and administrative workflows.  All sessions are held in person, with required registration and limited space. Dates, session […]

PNGC is excited to  launch a new AI Learning Series featuring an ethics-focused journal club and practical seminars. AI Ethics Journal ClubThese discussions will cover key issues in AI ethics, including bias and fairness in biomedical models, data governance, and responsible use of generative AI. Participants will receive a short reading list before each session. Our […]

Genome sequencing results can be used to train PRS models but suffer from computation and privacy limitations. A new web portal from Drs. Jin Jin and Bingxin Zhao uses GWAS summary statistics and novel pseudo-training methods to make the latest generation of PRS models more accessible. 

ur first batch of genetic data is available, and the quality is outstanding, indicating the sample collection protocol is robust. Since most ACAD participants are immigrants, immigration experience (languages, education, occupation transitions) could be a unique feature in disease development. Analyzing lifestyle data highlights the importance of the environment in AD risks and how genetics may interact with major life transitions.

The Alzheimer’s Genomics Database is a user-friendly AD-centric interactive knowledgebase and genome browser, which provides unrestricted access to GWAS summary statistics from the NIAGADS repository, as well as to annotated variants called from ongoing the Alzheimer’s Disease Sequencing Project’s (ADSP) joint-genotype calling efforts.  We sat down with Dr. Emily Greenfest-Allen, the architect of the Alzheimer’s Genomics Database, […]