Leadership
Gerard Schellenberg, PhD
Director, Penn Neurodegeneration Genomics Center
Professor, Pathology & Laboratory Medicine
Professor, Pathology & Laboratory Medicine
Genetics and genomics of Alzheimer’s Disease and related dementia.
Li-San Wang, PhD
Co-Director, Penn Neurodegeneration Genomics Center
Professor, Pathology & Laboratory Medicine
Professor, Pathology & Laboratory Medicine
Genetics of Alzheimer’s Disease and Related Dementia; computational methods for big data in genomics research.
Affiliated Faculty
Christopher (Casey) Brown, PhD
Associate Professor of Genetics
Functional human non-coding sequence variation; expression QTL analysis; high throughput approaches for fine-mapping of the causal variants underlying human disease.
Alice Chen-Plotkin, MD
Parker Family Professor of Neurology
Unbiased genomic- or proteomic-scale screens; mechanistic followup in relevant systems including neuronal culture and in vivo animal models
Alessandra Chesi, PhD
Assistant Professor of Pathology and Laboratory Medicine
Translating genetics findings for human neurodegenerative disorders into molecular mechanisms of disease. We use chromatin conformation capture, epigenomics and bioinformatics techniques to identify actionable target genes in human iPSC-derived neural cell models.
Shin-Yi Chou, PhD
Arthur F. Searing Professor of Economics, Lehigh University
Health economics and gene-environment interaction analysis of Alzheimer’s disease
Christos Davatzikos, PhD
Wallace T. Miller, Sr. Professor of Radiology
Biomedical Image Analysis, Machine learning in Imaging, Imaging Biomarkers of Neurologic and Neuropsychiatric Diseases.
Struan F.A. Grant, PhD
Professor of Pediatrics
Disease genomics, with a specific focus on pediatrics. High-throughput genotyping and sequencing technologies, combined with statistical and bioinformatic approaches.
David Irwin, MD
Assistant Professor of Neurology
Underlying pathology and genetics of neurodegenerative dementias, biomarkers.
F. Bradley Johnson, PhD
Associate Professor of Pathology and Laboratory Medicine
Molecular biology of aging, cell senescence, Werner syndrome, telomeres, recombination, G-quadruplexes, neurodegeneration, transplantation.
Jina Ko, PhD
Assistant Professor in Pathology and Laboratory Medicine and Bioengineering
We develop novel micro and nanotechnologies using bioengineering, molecular biology, and chemistry tools to address currently intractable diagnostic challenges for precision medicine.
Edward B. Lee, MD, PhD
Associate Professor of Pathology and Laboratory Medicine
Molecular pathways associated with neuropathologic inclusions in amyotrophic lateral sclerosis and frontotemporal lobar dementia.
Virginia M.-Yee Lee, PhD
John H. Ware 3rd Endowed Professor in Alzheimer's Research
Biology of tau, synucleins, TDP-43 and amyloid beta precursor proteins (APPs) in health and disease.
Wan-Ping Lee, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
Computational biology and bioinformatics; software and algorithm development for large-scale genomic data analysis; copy number variation and structural variant detection.
Yuk Yee Leung, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
small RNA and proteomic biomarkers for Alzheimer's disease and related dementias, genomic annotation and sequencing pipelines for Alzheimer's disease, RNA-seq bioinformatics
Mingyao Li, PhD
Professor of Biostatistics
Statistical genetics, bioinformatics and computational biology for high-throughput genetics/genomics data; single-cell sequencing analysis.
Iain Mathieson, PhD
Assistant Professor of Genetics
Population genetics, human evolution and the genetics of complex traits
Corey T. McMillan, PhD
Associate Professor, Neurology
Neurodegeneration, Neuroimaging, Biomarkers, Frontotemporal Degeneration (FTD), Parkinson's disease (PD), Alzheimer's disease (AD), Amyotrophic Lateral Sclerosis (ALS)
Adam Naj, PhD
Assistant Professor of Epidemiology in Biostatistics and Epidemiology
Genetic epidemiology for Alzheimer’s disease (AD) and other neurodegenerative diseases.
Jennifer E. Phillips-Cremins, PhD
Assistant Professor, Bioengineering (BE)
3D genome folding; Neurodevelopment; Neurodegenerative disease; Trinucleotide repeat expansion disorders; Epigenetics; Genomics
Ophir Shalem, PhD
Assistant Professor of Genetics
Christian J. Stoeckert Jr., PhD
Research Professor, Genetics
Computational biology and bioinformatics; genomics databases; ontology.
John Q. Trojanowski, MD, PhD
William Maul Measy - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein; Morphological, genetic, molecular biological and biochemical methods to study neurodegeneration.
Jung-Ying Tzeng, PhD
Professor of Statistics, North Carolina State University
Statistical methods for genetic and genomic studies; bioinformatics.
Vivianna M. Van Deerlin, MD, PhD
Professor, Pathology and Laboratory
Genetics of neurodegenerative diseases, in particular frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD).
Benjamin F. Voight, PhD
Associate Professor of Pharmacology and Genetics
Statistical genetics, computational biology, and population genetics-based approaches to understand the biological underpinnings and evolutionary history of human phenotypes.