Gerard Schellenberg, PhD
Director, Penn Neurodegeneration Genomics Center
Professor, Pathology & Laboratory Medicine
Genetics and genomics of Alzheimer’s Disease and related dementia.
Li-San Wang, PhD
Co-Director, Penn Neurodegeneration Genomics Center
Professor, Pathology & Laboratory Medicine
Genetics of Alzheimer’s Disease and Related Dementia; computational methods for big data in genomics research.

Affiliated Faculty

Alice Chen-Plotkin, MD
Parker Family Professor of Neurology
Unbiased genomic- or proteomic-scale screens; mechanistic followup in relevant systems including neuronal culture and in vivo animal models
Alessandra Chesi, PhD
Assistant Professor of Pathology and Laboratory Medicine
Translating genetics findings for human neurodegenerative disorders into molecular mechanisms of disease. We use chromatin conformation capture, epigenomics and bioinformatics techniques to identify actionable target genes in human iPSC-derived neural cell models.
Shin-Yi Chou, PhD
Arthur F. Searing Professor of Economics, Lehigh University
Health economics and gene-environment interaction analysis of Alzheimer’s disease
Tiffany Chow, MD
Adjunct Professor of Pathology and Laboratory Medicine
Dr. Chow is an industry physician with extensive experience in clinical research in academic behavioral neuroscience elucidating the neurobiology of Alzheimer’s and other dementias, applying radioligand PET imaging and functional neuroimaging methods, neuropsychiatric assessments, and qualitative work to report on caregiver needs for education and support. She has been a thought leader in frontotemporal dementias, Alzheimer’s disease clinical trial design, and caregiver advocacy in cognitive disorders through career-long networking. She is the Clinical Core Lead for the NIA-funded Asian Cohort in Alzheimer’s Disease study.
Christos Davatzikos, PhD
Wallace T. Miller, Sr. Professor of Radiology
Biomedical Image Analysis, Machine learning in Imaging, Imaging Biomarkers of Neurologic and Neuropsychiatric Diseases.
Yanxiang Deng, PhD
Assistant Professor of Pathology and Laboratory Medicine
We are developing new tools to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells. These novel technologies will greatly improve our ability to study tissue complexity and reveal the salient features of tissue architecture in physiology and disease.
Struan F.A. Grant, PhD
Professor of Pediatrics
Disease genomics, with a specific focus on pediatrics. High-throughput genotyping and sequencing technologies, combined with statistical and bioinformatic approaches.
David Irwin, MD
Assistant Professor of Neurology
Underlying pathology and genetics of neurodegenerative dementias, biomarkers.
Jin Jin, PhD
Assistant Professor of Biostatistics
I lead a broad research program in developing statistical methods and computational tools to address cutting-edge problems in public health by integrating large-scale, multi-source datasets. My lab has been developing powerful methods for multi-modal risk model development to characterize and understand health disparities and improve health outcomes for underrepresented minority populations. Our endeavors in the field have been reflected in our involvement in building risk models based on genetic, behavioral, and sociodemographic factors, which has led to insights into nephrology, mental health, and COVID-19.
F. Bradley Johnson, PhD
Associate Professor of Pathology and Laboratory Medicine
Molecular biology of aging, cell senescence, Werner syndrome, telomeres, recombination, G-quadruplexes, neurodegeneration, transplantation.
Jina Ko, PhD
Assistant Professor in Pathology and Laboratory Medicine and Bioengineering
We develop novel micro and nanotechnologies using bioengineering, molecular biology, and chemistry tools to address currently intractable diagnostic challenges for precision medicine.
Edward B. Lee, MD, PhD
Associate Professor of Pathology and Laboratory Medicine
Molecular pathways associated with neuropathologic inclusions in amyotrophic lateral sclerosis and frontotemporal lobar dementia.
Virginia M.-Yee Lee, PhD
John H. Ware 3rd Endowed Professor in Alzheimer's Research
Biology of tau, synucleins, TDP-43 and amyloid beta precursor proteins (APPs) in health and disease.
Wan-Ping Lee, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
Computational biology and bioinformatics; software and algorithm development for large-scale genomic data analysis; copy number variation and structural variant detection.
Yuk Yee Leung, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
small RNA and proteomic biomarkers for Alzheimer's disease and related dementias, genomic annotation and sequencing pipelines for Alzheimer's disease, RNA-seq bioinformatics
Mingyao Li, PhD
Professor of Biostatistics
Statistical genetics, bioinformatics and computational biology for high-throughput genetics/genomics data; single-cell sequencing analysis.
Iain Mathieson, PhD
Assistant Professor of Genetics
Population genetics, human evolution and the genetics of complex traits
Corey T. McMillan, PhD
Associate Professor, Neurology
Neurodegeneration, Neuroimaging, Biomarkers, Frontotemporal Degeneration (FTD), Parkinson's disease (PD), Alzheimer's disease (AD), Amyotrophic Lateral Sclerosis (ALS)
Adam Naj, PhD
Assistant Professor of Epidemiology in Biostatistics and Epidemiology
Genetic epidemiology for Alzheimer’s disease (AD) and other neurodegenerative diseases.
Jennifer E. Phillips-Cremins, PhD
Assistant Professor, Bioengineering (BE)
3D genome folding; Neurodevelopment; Neurodegenerative disease; Trinucleotide repeat expansion disorders; Epigenetics; Genomics
Ophir Shalem, PhD
Assistant Professor of Genetics
Christian J. Stoeckert Jr., PhD
Research Professor, Genetics
Computational biology and bioinformatics; genomics databases; ontology.
Jung-Ying Tzeng, PhD
Professor of Statistics, North Carolina State University
Statistical methods for genetic and genomic studies; bioinformatics.
Vivianna M. Van Deerlin, MD, PhD
Professor, Pathology and Laboratory
Genetics of neurodegenerative diseases, in particular frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD).
Benjamin F. Voight, PhD
Associate Professor of Pharmacology and Genetics
Statistical genetics, computational biology, and population genetics-based approaches to understand the biological underpinnings and evolutionary history of human phenotypes.

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