Event categories: PNGC Journal Club

Presenter: Shilpa Sonti Paper: Functional regulatory variants implicate distinct transcriptional networks in dementia.

Presenter: Shannon LaubPaper: Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements.

Presenter: Sandhya RamachandranPaper: Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer’s disease Please contact Maureen Kirsch for the Zoom information.

Presenter: Bormeh FaryeanPaper: Identification of novel risk loci, causal insights, and heritable risk for Parkinson’s disease: a meta-analysis of genome-wide association studies

Presenter: Ting Shen, Postdoctoral ResearcherPaper: Mapping gene transcription and neurocognition across human neocortex.

Presenter: Kerry NixPaper: Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Please contact Maureen Kirsch for the link to join.

Presenter: Jeffrey CifelloPaper: Population-level variation in enhancer expression identifies disease mechanisms in the human brain

Presenter: Barbara SpencerPaper: Integrative genetic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes Please contact Maureen Kirsch for the link to join.

Presenter: Adam NajPaper: Somatic genomic changes in single Alzheimer’s disease neurons. Please contact Maureen Kirsch for the link to join.

Presenter: EunRan SuhPaper: Disease variant prediction with deep generative models of evolutionary data. Please contact Maureen Kirsch for the link to join.

Presenter: Shannon LaubPaper: CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states Please contact Maureen Kirsch for the link to join.