Event categories: PNGC Journal Club

Presenter: Kerry NixPaper: Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Please contact Maureen Kirsch for the link to join.

Presenter: Jeffrey CifelloPaper: Population-level variation in enhancer expression identifies disease mechanisms in the human brain

Presenter: Barbara SpencerPaper: Integrative genetic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes Please contact Maureen Kirsch for the link to join.

Presenter: Adam NajPaper: Somatic genomic changes in single Alzheimer’s disease neurons. Please contact Maureen Kirsch for the link to join.

Presenter: EunRan SuhPaper: Disease variant prediction with deep generative models of evolutionary data. Please contact Maureen Kirsch for the link to join.

Presenter: Shannon LaubPaper: CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states Please contact Maureen Kirsch for the link to join.

Presenter: David DaiPaper: Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions Please contact Maureen Kirsch for the link to join.

Presenter: Rueben DasPaper: Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology Please contact Maureen Kirsch for the link to join and access to the article.

Presenter: Beth BurtonPaper: Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer disease brains Please contact Maureen Kirsch for the link to join.

Presenter: Rachel Kolster Paper: Genome-wide association study and functional validation implicates JADE1 in tauopathy. Please contact Maureen Kirsch for the link to join.