Alessandra Chesi recently joined the Department of Pathology and Laboratory Medicine in the Division of Experimental Pathology, as well as the Penn Neurodegeneration Genomics Center. Alessandra joins us from CHOP where, from 2013-2020, she was a Bioinformatic Specialist in Struan Grant’s lab and the Center for Spatial and Functional Genomics. Before joining CHOP, Alessandra worked in the laboratory […]
The NIA is excited to announce the release of the latest genomics data set from the Alzheimer’s Disease Sequencing Project (ADSP). The NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) is a vital tool as we seek to better understand genes that increase risk for — or protection from — AD/ADRD. Researchers can now access […]
Last month, on November 12 and 13, the Alzheimer’s Disease Genetics Consortium (ADGC) 10-Year Symposium took place at the Inn at Penn in Philadelphia, PA. The event was sponsored by the Perelman School of Medicine and the Department of Pathology and Laboratory Medicine, and it was organized by ADGC, Penn Neurodegeneration Genomics Center (PNGC) and […]
- Human genetics helps us understand the biology of Alzheimer’s and identify drug targets.
- Improvements in technology such as sequencing and gene therapy are promising.
- Large sample sizes and rich phenotypes are critical to finding new AD genes.
- Data visualization and outreach will encourage closer collaboration among the research community.
The Alzheimer’s Disease Genetics Consortium (ADGC) and and the International Genomics of Alzheimer’s Project (IGAP) performed the largest genetic wide association study (GWAS) to date to discover risk loci for LOAD. Their meta-analysis implicates Abeta, Tau, immunity and lipid processing. The paper on Alzheimer’s disease genetic association has been published on bioRxiv and can be […]
PNGC is pleased to announce the release of the INFERNO (INFERing the molecular mechanisms of NOncoding genetic variants) method (http://inferno.lisanwanglab.org). Since the majority of variants that genome-wide association studies (GWAS) identify are outside of protein-coding genes and may be proxies of truly causal variants that are inherited together in linkage disequilibrium (LD), there is a […]
NIAGADS is pleased to announce the release of the Genomics Database v. 3.1, which features a major face lift intended to improve user experience. NIAGADS GenomicsDB is a public resource that researchers can access without having to formally request data. This release greatly improves the visualization of summary statistics on the genome browser section of […]
“Can the machine invasion help save your brain?” CBS explores this question in an October 27 article about the development of technology as it relates to advances in Alzheimer’s disease. While the amount of genetic data available has increased in recent years, the speed at which it gets sifted through also needs to increase in […]