PNGC is pleased to announce the release of “HIPPIE2: a method for fine-scale identification of physically interacting chromatin regions”. Because most regulatory chromatin interactions are mediated by numerous transcription factors (TFs) and involve physically interacting regions (PIRs), HIPPIE2 was developed to map these elements and interactions at a much finer scale (sub-1Kb resolution). HIPPIE2 is […]
The NIA is excited to announce the release of the latest genomics data set from the Alzheimer’s Disease Sequencing Project (ADSP). The NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) is a vital tool as we seek to better understand genes that increase risk for — or protection from — AD/ADRD. Researchers can now access […]
PNGC is pleased to announce the release of SparkINFERNO, a next-generation of INFERNO (INFERring the molecular mechanisms of NOn-coding genetic variants) bioinformatics pipeline. While genome-wide association studies (GWASs) have identified over 70,000 disease-associated genetic variants, most hits are in the non-coding region, which makes their interpretation difficult. SparkINFERNO, a scalable, high-throughput bioinformatics pipeline characterizing noncoding […]
Last month, on November 12 and 13, the Alzheimer’s Disease Genetics Consortium (ADGC) 10-Year Symposium took place at the Inn at Penn in Philadelphia, PA. The event was sponsored by the Perelman School of Medicine and the Department of Pathology and Laboratory Medicine, and it was organized by ADGC, Penn Neurodegeneration Genomics Center (PNGC) and […]
PNGC members had a great experience at the Alzheimer’s Association International Conference (AAIC) this year. AAIC took place in Los Angeles from July 12-17. We presented four posters during the conference and the National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) exhibited for the first time. In addition, Dr. Adam Naj […]
PNGC is pleased to announce that Dr. Fanny Leung, Research Assistant Professor at the University of Pennsylvania and PNGC faculty member, recently had an application funded under the 2019 Biomarkers Across Neurodegenerative Diseases (BAND 3) Program. This award is sponsored by The Alzheimer’s Association, Alzheimer’s Research UK (ARUK), The Michael J. Fox Foundation for Parkinson’s Research (MJFF), and the Weston Brain […]
AD/PDTM 2019, the 14th International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders, was held in Lisbon on March 26-31. The conference is at the forefront of unraveling the mechanisms and improving the treatment of Alzheimer’s, Parkinson’s and other related neurodegenerative diseases. AD/PDTM Conferences uniquely combine distinct neurodegenerative diseases in one setting and examine their similarities and differences;
On Friday, April 12, Genomics and Computational Biology student Alex Amlie-Wolf defended his Ph.D. thesis. His work during his time as a student in the GCB program included the development of the INFERNO method, a software tool and web server that integrates public genomic data with GWAS summary statistics to characterize the mechanisms of noncoding […]
The International Genomics of Alzheimer’s Project (IGAP) has identified five new genes that increase risk for Alzheimer’s Disease, as well as confirmed the association of another 20 genes and AD risk. The consortium has also found that tau related mutations could play an earlier role in disease development than previously understood. IGAP is led by […]
PNGC is pleased to announce the release of the DASHR v2.0 database of human small non-coding RNAs (sncRNAs). DASHR v2.0 is freely available at https://lisanwanglab.org/DASHRv2. This is an extremely useful resource and reference for the community studying non-coding RNAs and their diverse roles in often tissue-specific cellular processes related to human diseases. DASHR (Database of […]
Recently, Penn Medicine News wrote a press release describing the new NIAGADS Data Sharing Service (DSS), which will distribute genomic data to qualified investigators. Initially, whole-genome sequence data will be available for 5,000 subjects, with more data to be released within a year. “Genetic findings for Alzheimer’s disease are critical for identifying targets for therapeutic […]
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