Alzheimer’s Disease Variant Portal (ADVP): The Newest Curated Population-specific Alzheimer’s Disease Genetics Resource

By Fernanda Ruiz, NOVA Research Company Alzheimer’s Disease (AD) is a devastating disease that affects more than 6 million Americans, a number that is projected to increase considerably in the near future. Scientists looking for the causes of AD use different approaches, including genomic studies like genome-wide association studies (GWAS), that detect associations between genetic […]

Structural Variant Toolbox: Discovering, Genotyping, and Merging SVs in Alzheimer’s Disease Research

By Fernanda Ruiz, NOVA Research Company Alzheimer’s disease (AD) is a degenerative disease that likely is caused by a combination of environmental, lifestyle, and genetic factors, and increasing age. Alzheimer’s Disease Sequencing  Project (ADSP) researchers are focused on gaining further insights into the genetic component of this disease, including the role of structural variants (SVs), […]

Genome Center for Alzheimer’s Disease Receives $20 Million Five-Year Renewal

PNGC is excited to announce that the Genome Center for Alzheimer’s Disease (GCAD) has received a 5-year grant renewal totaling $20 million to continue their work. GCAD, a collaborative research center between Penn, Boston University, Case Western Reserve University, Columbia University, the University of Miami, and the University of Indiana, aims to identify AD-related genes […]

Alessandra Chesi, PhD: Advancing Toward Druggable Targets

By Kathy Sedgwick, NOVA Research Company Dr. Alessandra Chesi joined the University of Pennsylvania faculty as an Assistant Professor of Pathology and Laboratory Medicine in July 2020. Her work at Penn focuses on the application of transformative technologies as well as functional genomics and systems biology approaches toward gaining insight into the regulation and identity […]

PNGC Co-Director Li-San Wang to Present at the 2021 NIH Alzheimer’s Research Summit

The NIH will host their 2021 Alzheimer’s Research Summit April 19-22. This virtual summit will convene leading AD scientists, innovators, and public health advocates to showcase progress in Alzheimer’s disease research and ideas for supporting the goal of precision medicine for Alzheimer’s treatment and prevention. On Tuesday, April 20, Drs Li-San Wang (Penn) and Timothy […]

PNGC at AAIC 2020 Roundup

When the Covid-19 pandemic hit the globe hard this spring, Alzheimer’s Disease researchers weren’t sure what was going to happen to their annual Alzheimer’s Association International Conference (AAIC), originally planned for Amsterdam. AAIC’s goal is to convene the world’s leaders in dementia science to share research discoveries that will lead to methods of prevention and treatment, and improvements in diagnosis for Alzheimer’s disease—it would have been a huge disappointment for the AD research community to miss out on their conference.

Welcome New Faculty Alessandra Chesi, PhD

Alessandra Chesi recently joined the Department of Pathology and Laboratory Medicine in the Division of Experimental Pathology, as well as the Penn Neurodegeneration Genomics Center. Alessandra joins us from CHOP where, from 2013-2020, she was a Bioinformatic Specialist in Struan Grant’s lab and the Center for Spatial and Functional Genomics. Before joining CHOP, Alessandra worked in the laboratory […]

The Founders of PNGC

The Penn Neurodegeneration Genomics Center was founded three years ago by Dr. Gerard Schellenberg and Dr. Li-San Wang. Together they have contributed over 40 years of their lives to Alzheimer’s research. How did you get started in Alzheimer’s research? Dr. Schellenberg: Dr. Schellenberg was offered a grant in 1982 for Alzheimer’s research. At the time, […]

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