PNGC Blog

Our random and intentional thoughts

PNGC Hosts Guest Seminar on Proteomics and Tauopathy

Judith Steen, an Associate Professor of Neurology at Harvard Medical School, spoke at Penn at the beginning of May. Dr. Steen has conducted research in the field of proteomics (the study of the structure and function of proteins), as well as the systems biology of proteopathies, or diseases due to abnormal protein aggregations.  In particular, […]

The State of Alzheimer’s Disease Genetics Research: A Discussion with Dr. Gerard Schellenberg

  • Human genetics helps us understand the biology of Alzheimer’s and identify drug targets.
  • Improvements in technology such as sequencing and gene therapy are promising.
  • Large sample sizes and rich phenotypes are critical to finding new AD genes.
  • Data visualization and outreach will encourage closer collaboration among the research community.

Largest GWAS To Date Implicates Abeta, Tau, Immunity and Lipid Processing in LOAD

The Alzheimer’s Disease Genetics Consortium (ADGC) and and the International Genomics of Alzheimer’s Project (IGAP) performed the largest genetic wide association study (GWAS) to date to discover risk loci for LOAD. Their meta-analysis implicates Abeta, Tau, immunity and lipid processing. The paper on Alzheimer’s disease genetic association has been published on bioRxiv and can be […]

PNGC Releases INFERNO

PNGC is pleased to announce the release of the INFERNO (INFERing the molecular mechanisms of NOncoding genetic variants) method (http://inferno.lisanwanglab.org). Since the majority of variants that genome-wide association studies (GWAS) identify are outside of protein-coding genes and may be proxies of truly causal variants that are inherited together in linkage disequilibrium (LD), there is a […]

Dr. Brad Hyman Speaks at Penn

Penn Neurodegenerative and Genomics Center was fortunate to have Dr. Brad Hyman visit from Boston and give a seminar style presentation on November 29. Dr. Hyman has worked at Massachusetts General Hospital for 25 years seeing patients with Alzheimer’s disease, and he currently serves as the Alzheimer’s Unit Director at the Institute for Neurodegenerative Disease […]