The Penn Neurodegeneration Genomics Center was founded three years ago by Dr. Gerard Schellenberg and Dr. Li-San Wang. Together they have contributed over 40 years of their lives to Alzheimer’s research. How did you get started in Alzheimer’s research? Dr. Schellenberg: Dr. Schellenberg was offered a grant in 1982 for Alzheimer’s research. At the time, […]
PNGC members had a great experience at the Alzheimer’s Association International Conference (AAIC) this year. AAIC took place in Los Angeles from July 12-17. We presented four posters during the conference and the National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) exhibited for the first time. In addition, Dr. Adam Naj […]
PNGC is pleased to announce that Dr. Fanny Leung, Research Assistant Professor at the University of Pennsylvania and PNGC faculty member, recently had an application funded under the 2019 Biomarkers Across Neurodegenerative Diseases (BAND 3) Program. This award is sponsored by The Alzheimer’s Association, Alzheimer’s Research UK (ARUK), The Michael J. Fox Foundation for Parkinson’s Research (MJFF), and the Weston Brain […]
AD/PDTM 2019, the 14th International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders, was held in Lisbon on March 26-31. The conference is at the forefront of unraveling the mechanisms and improving the treatment of Alzheimer’s, Parkinson’s and other related neurodegenerative diseases. AD/PDTM Conferences uniquely combine distinct neurodegenerative diseases in one setting and examine their similarities and differences;
On Friday, April 12, Genomics and Computational Biology student Alex Amlie-Wolf defended his Ph.D. thesis. His work during his time as a student in the GCB program included the development of the INFERNO method, a software tool and web server that integrates public genomic data with GWAS summary statistics to characterize the mechanisms of noncoding […]
The International Genomics of Alzheimer’s Project (IGAP) has identified five new genes that increase risk for Alzheimer’s Disease, as well as confirmed the association of another 20 genes and AD risk. The consortium has also found that tau related mutations could play an earlier role in disease development than previously understood. IGAP is led by […]
Penn Neurodegeneration Genomics Center (PNGC) had the exciting opportunity to host Dr. Badri Vardarajan last semester. Dr. Vardarajan gave a seminar style talk around some of the work he and his team are doing at Columbia, and we’ve recapped below. Dr. Vardarajan has a background in computational biology and is an Assistant Professor of Bioinformatics […]
PNGC is pleased to announce the release of the DASHR v2.0 database of human small non-coding RNAs (sncRNAs). DASHR v2.0 is freely available at https://lisanwanglab.org/DASHRv2. This is an extremely useful resource and reference for the community studying non-coding RNAs and their diverse roles in often tissue-specific cellular processes related to human diseases. DASHR (Database of […]
Recently, Penn Medicine News wrote a press release describing the new NIAGADS Data Sharing Service (DSS), which will distribute genomic data to qualified investigators. Initially, whole-genome sequence data will be available for 5,000 subjects, with more data to be released within a year. “Genetic findings for Alzheimer’s disease are critical for identifying targets for therapeutic […]
PNGC is pleased to announce the release of the SPAR web server for small RNA-seq data analysis. Small non-coding RNAs (<200 nts, sncRNAs) play important regulatory roles by binding to mRNA and associating with transcription factor complexes in most eukaryotes, but only a fraction of sncRNAs, which include many different classes, have been identified and […]
Judith Steen, an Associate Professor of Neurology at Harvard Medical School, spoke at Penn at the beginning of May. Dr. Steen has conducted research in the field of proteomics (the study of the structure and function of proteins), as well as the systems biology of proteopathies, or diseases due to abnormal protein aggregations. In particular, […]
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